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Defining clinical outcome pathways
Drug Discovery Today, 2022Here, we propose a broad concept of 'Clinical Outcome Pathways' (COPs), which are defined as a series of key molecular and cellular events that underlie therapeutic effects of drug molecules. We formalize COPs as a chain of the following events: molecular initiating event (MIE) → intermediate event(s) → clinical outcome.
Daniel, Korn +14 more
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Anesthesiology Clinics of North America, 2005
This article discusses the impact of anemia in the context of the perioperative setting. Relevant data from animal and human studies, the adaptive mechanisms in anemia, and current views on transfusion triggers are evaluated. Recommendations are provided for the anesthesiologist for transfusion of red blood cells.
Mercy, Kuriyan, Jeffrey L, Carson
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This article discusses the impact of anemia in the context of the perioperative setting. Relevant data from animal and human studies, the adaptive mechanisms in anemia, and current views on transfusion triggers are evaluated. Recommendations are provided for the anesthesiologist for transfusion of red blood cells.
Mercy, Kuriyan, Jeffrey L, Carson
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Hematology Meeting Reports, 2009
In thalassemia, myelodysplastic syndrome (MDS) and sickle cell disease (SCD), long-term substitution therapy for anemia results in toxic iron overload which constitutes a significant medical problem. As humans have no physiological mechanism to excrete excess iron, this is deposited in the form of ferritin and hemosiderin in the liver, spleen, many ...
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In thalassemia, myelodysplastic syndrome (MDS) and sickle cell disease (SCD), long-term substitution therapy for anemia results in toxic iron overload which constitutes a significant medical problem. As humans have no physiological mechanism to excrete excess iron, this is deposited in the form of ferritin and hemosiderin in the liver, spleen, many ...
openaire +2 more sources