Results 51 to 60 of about 1,567,646 (250)

Infantile Central Nervous System Juvenile Xanthogranuloma With Somatic CSF1R Mutation Responsive to Imatinib Monotherapy

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Juvenile xanthogranuloma (JXG) of the central nervous system (CNS) is a rare non‐Langerhans cell histiocytosis. CSF1R mutations have been reported for peripheral JXG, but not in CNS JXG. A 3‐month‐old male presented with fever, lymphadenopathy, and macrocephaly with bulging fontanelles.
Sima Vazquez, Kayla Etienne, Long Di, Valerie Martinez‐Torres, Andrew Rosenberg, Sakir H. Gultekin, Aditi Dhir, Bradley Gampel, Heather J. McCrea   +8 more
wiley   +1 more source

Comprehensive multi-omics analysis of tandem duplicator phenotypes in non-small cell lung cancer

Frontiers in Medicine
IntroductionThe Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC).MethodsMulti-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data ...
Jie Li, Xinyan Pan, Yanting Bi, Jian Huang, Jun Peng, ChunLing Bai, Jianhong Hou, Yang Chen   +7 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Weakly supervised deep learning for cutaneous squamous and basal cell carcinoma in whole‐slide histopathology

The Journal of Pathology: Clinical Research
Distinguishing infiltrative basal cell carcinoma (BCC) from poorly differentiated cutaneous squamous cell carcinoma (cSCC) remains a significant histopathological challenge.
Anne Petzold, Anja Wessely, Stefan Schliep, Hong Jiang, Manuel Tran, Elias AT Koch, Tingying Peng, Hans Starz, Carola Berking, Carsten Marr, Markus V Heppt   +10 more
doaj   +1 more source

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Usefulness of cerebrospinal fluid analysis in dogs and cats with suspected intracranial disease and normal magnetic resonance imaging

Frontiers in Veterinary Science
Cerebrospinal fluid (CSF) analysis is a common diagnostic tool in the investigation of neurological presentations. Whether its routine use after every brain magnetic resonance imaging (MRI) is warranted is debated amongst clinicians, and its usefulness ...
Susana R. Monforte Monteiro, Luisa De Risio, Lisa Alves, An E. Vanhaesebrouck   +3 more
doaj   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Challenging the Clinical Paradigm of Hepatozoon canis: A Primary Pathogen Causing Clinically Significant Disease at Low Parasitaemia and a Chronic Inflammatory State

Veterinary Medicine and Science
Background Hepatozoon canis is an important canine pathogen transmitted by the brown dog tick, Rhipicephalus sanguineus, causing a vector‐borne disease with variable clinical severity.
Somayeh Bahrami, Zahra Mashayekhi, Seyedeh Misagh Jalali, Mohammad Khosravi, Mohammad Rajabloo   +4 more
doaj   +1 more source

Beyond Individual Acute Phase Protein Assessments: Introducing the Acute Phase Index (API) as a Prognostic Indicator in Dogs with Malignant Neoplasia

Veterinary Sciences
Acute phase proteins (APPs) are part of the innate immune response, changing during inflammation. An Acute Phase Index (API) is a calculated value that combines multiple APPs.
Martina Baldin, Maria Elena Gelain, Giacomo Marolato, Silvia Bedin, Michele Berlanda, Manuela Zanetti, Filippo Torrigiani, Alessia Giordano, Pierangelo Moretti, Donatella Scavone, Federico Bonsembiante   +10 more
doaj   +1 more source

Reassessing Bone Marrow Aspirate and Trephine Biopsies in Staging for Paediatric and Young Adult Patients With Ewing Sarcoma and Rhabdomyosarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma (ES) and rhabdomyosarcoma (RMS) are aggressive malignancies in children and adolescents where metastases impact prognosis. 18F‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography/computed tomography (FDG‐PET/CT) and bone marrow aspirate and trephine biopsies (BMAT) are used to identify disease involvement.
Imogen Andrews, Bruce Goodwin, Lauren Buckley, Rick Walker   +3 more
wiley   +1 more source