Results 71 to 80 of about 1,686,489 (300)

Comprehensive multi-omics analysis of tandem duplicator phenotypes in non-small cell lung cancer

Frontiers in Medicine
IntroductionThe Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC).MethodsMulti-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data ...
Jie Li, Xinyan Pan, Yanting Bi, Jian Huang, Jun Peng, ChunLing Bai, Jianhong Hou, Yang Chen   +7 more
doaj   +1 more source

Valores de referência do tempo de protrombina (TP) e tempo de tromboplastina parcial ativada (TTPa) em cães Reference ranges of prothrombin time (PT) and activated partial thromboplastin time (aPTT) in dogs

Ciência Rural, 2005
Os fatores de coagulação são parte integrante da hemostasia normal, e tanto as coagulopatias hereditárias como adquiridas que envolvem este sistema são de grande importância veterinária, geralmente evidenciadas por manifestações clínicas, tais como ...
Sonia Terezinha dos Anjos Lopes, Mauren Picada Emanuelli, Claudete Schmidt, Alceu Gaspar Raiser, Alexandre Mazzanti, Aline Souza Alves   +5 more
doaj   +1 more source

Anatomic and clinical pathology : proceedings of the VIII World congress of anatomic and clinical pathology /

, 1973
Sponsored by the World Association of Anatomic and Clinical Pathology Societies.Met lit ...
World Association of Anatomic and Clinical Pathology Societies., World congress of Anatomic and Clinical Pathology(8 :1972 :Munich), Nordmann, Martin,1895-1980(viaf)25000176edt, Excerpta Medica Foundation.   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Weakly supervised deep learning for cutaneous squamous and basal cell carcinoma in whole‐slide histopathology

The Journal of Pathology: Clinical Research
Distinguishing infiltrative basal cell carcinoma (BCC) from poorly differentiated cutaneous squamous cell carcinoma (cSCC) remains a significant histopathological challenge.
Anne Petzold, Anja Wessely, Stefan Schliep, Hong Jiang, Manuel Tran, Elias AT Koch, Tingying Peng, Hans Starz, Carola Berking, Carsten Marr, Markus V Heppt   +10 more
doaj   +1 more source

Usefulness of cerebrospinal fluid analysis in dogs and cats with suspected intracranial disease and normal magnetic resonance imaging

Frontiers in Veterinary Science
Cerebrospinal fluid (CSF) analysis is a common diagnostic tool in the investigation of neurological presentations. Whether its routine use after every brain magnetic resonance imaging (MRI) is warranted is debated amongst clinicians, and its usefulness ...
Susana R. Monforte Monteiro, Luisa De Risio, Lisa Alves, An E. Vanhaesebrouck   +3 more
doaj   +1 more source

Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimer's Disease Pathology

, 2011
Epidemiological studies suggest that systemic use of non-steroidal anti-inflammatory drugs (NSAIDs) can prevent or retard the development of Alzheimer's disease (AD).
Eikelenboom, P., Hoozemans, J. J. M., J. M. Rozemuller, Veerhuis, R., Hoozemans, J.J.M., Rozemuller, J. M., P. Eikelenboom, Rozemuller, A.J.M., R. Veerhuis, J. J.M. Hoozemans   +9 more
core   +1 more source

The use of digital pathology and image analysis in clinical trials [PDF]

, 2019
Digital pathology and image analysis potentially provide greater accuracy, reproducibility and standardisation of pathology-based trial entry criteria and endpoints, alongside extracting new insights from both existing and novel features.
Howlett, Emily, Traub, S, Hall, Andy, Craig, Clare, Rittscher, Jens, Thomas, GJ, Oien, Karin, da Silva, M, Katugampola, Sidath, Pell, R, Snead, David, West, N, Jones, Louise J, Craig, C, UK National Cancer Research Institute (NCRI) Cellular-Molecular Pathology (CM-Path) quality assurance working group,, Snead, D, On behalf of the UK National Cancer Research Institute (NCRI) Cellular-Molecular Pathology (CM-Path) quality assurance working group, Robert Pell, Jones, LJ, Thomas, Gareth J., Rodriguez‐Justo, Manuel, Mirabile, Ilaria, Max Robinson, Pell, Robert, James, J, Driskell, OJ, Stevenson, Laura, Nasir Rajpoot, Rees, G, Mirabile, I, Oien, K, Sloan, P, Robinson, M, Pitman, Helen, Beecham, Joseph M, Robinson, Max, Hartridge‐Lambert, Sidonie, Salto-Tellez, M, Morden, J, Hall, A, Cheang, M, Karin Oien, Elliott, P, Thomas, Gareth J, Rajpoot, Nasir, Beecham, JM, Verrill, Clare, Traub, Stephanie, Hartridge-Lambert, S, da Silva, Maria, Jens Rittscher, Morden, James, West, Nicholas P, Rees, Gabrielle, Howlett, E, Verrill, C, Rittscher, J, Driskell, Owen J, Sloan, Philip, Rajpoot, Nasir M. (Nasir Mahmood), David Snead, Blagden, S, James, Jacqueline, Katugampola, S, Clare Verrill, Pitman, H, Stevenson, L, Helen Pitman, Rodriguez-Justo, M, Elliott, Philip, Salto‐Tellez, Manuel, Blagden, Sarah, Rajpoot, N, Cheang, Maggie   +73 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source