Results 71 to 80 of about 5,794,890 (214)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Clinicopathological analysis of 124 cardiac tumors: a single-center retrospective study

Frontiers in Cardiovascular Medicine
ObjectiveTo characterize the clinicopathological features, pathological spectrum, and anatomical distribution of cardiac tumors and to evaluate the diagnostic challenges associated with these rare lesions.MethodsA retrospective analysis was performed on ...
Shuai Luo, Xinyi Xu, Die He, Jinjing Wang   +3 more
doaj   +1 more source

Fiebres virales hemorrágicas en Suramérica

Biomédica: revista del Instituto Nacional de Salud, 2002
El artículo revisa la epidemiología y rasgos distintivos de tres fiebres virales hemorrágicas (dengue hemorrágico, fiebre amarilla y fiebre hemorrágica por arenavirus), que han emergido como serios problemas de salud pública en Suramérica.
Robert B. Tesh
doaj   +1 more source

Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimer's Disease Pathology

, 2011
Epidemiological studies suggest that systemic use of non-steroidal anti-inflammatory drugs (NSAIDs) can prevent or retard the development of Alzheimer's disease (AD).
Eikelenboom, P., Hoozemans, J. J. M., J. M. Rozemuller, Veerhuis, R., Hoozemans, J.J.M., Rozemuller, J. M., P. Eikelenboom, Rozemuller, A.J.M., R. Veerhuis, J. J.M. Hoozemans   +9 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Weakly supervised deep learning for cutaneous squamous and basal cell carcinoma in whole‐slide histopathology

The Journal of Pathology: Clinical Research
Distinguishing infiltrative basal cell carcinoma (BCC) from poorly differentiated cutaneous squamous cell carcinoma (cSCC) remains a significant histopathological challenge.
Anne Petzold, Anja Wessely, Stefan Schliep, Hong Jiang, Manuel Tran, Elias AT Koch, Tingying Peng, Hans Starz, Carola Berking, Carsten Marr, Markus V Heppt   +10 more
doaj   +1 more source

Comprehensive multi-omics analysis of tandem duplicator phenotypes in non-small cell lung cancer

Frontiers in Medicine
IntroductionThe Tandem Duplicator Phenotype (TDP) is a prominent genomic metric prevalent in non-small cell lung cancer (NSCLC).MethodsMulti-omics samples including DNA copy number, transcriptomics, somatic single-nucleotide variations, clinical data ...
Jie Li, Xinyan Pan, Yanting Bi, Jian Huang, Jun Peng, ChunLing Bai, Jianhong Hou, Yang Chen   +7 more
doaj   +1 more source

Gastrointestinal pathology : recent developments and concepts

, 2014
Editorial: This issue of the Journal of Clinical Pathology comprises a series of review articles on some of the latest developments in gastrointestinal ...
Montgomery, Elizabeth A., Chetty, Runjan, Lee, C. S., Lee, Cheok Soon (R13259), Montgomery, E. A., Chetty, R.   +5 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source