Results 71 to 80 of about 1,567,646 (250)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The impact of age on the Na:K ratio: observations from a general canine population
Frontiers in Veterinary ScienceIntroductionThe sodium-to-potassium (Na:K) ratio is commonly used as a screening criterion for hyponatremic and/or hyperkalemic hypoadrenocorticism (HA), a serious endocrine disorder in dogs characterized by non-specific clinical signs and variable ...
Polina Zemko +3 more
doaj +1 more source
Miranda’s Donkey: a review of published studies with insights on clinical pathology research for breed’s preservation [PDF]
Ciência Rural: Miranda’s donkey is an autochthonous asinine breed from northern Portugal classified as endangered by the Food and Agriculture Organization. Research on Miranda’s donkey in several scientific areas is important to standardize the breed and to assist ...
Grasiene Silva +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Journal of Veterinary Internal MedicineBackground Urine neutrophil gelatinase‐associated lipocalin (uNGAL) is a biomarker for the early diagnosis of AKI. Objectives To evaluate uNGAL in dogs with non‐associative immune mediated hemolytic anemia (IMHA) and to evaluate whether uNGAL correlates ...
Vasiliki Lantzaki +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Plasma concentration of thrombopoietin in dogs with immune thrombocytopenia
Journal of Veterinary Internal MedicineBackground Immune thrombocytopenia (ITP) is a common cause of severe thrombocytopenia in dogs. The pathogenesis of nonassociative, primary ITP (pITP) appears complex, with ill‐defined thrombopoietic response.
Marjory B. Brooks +7 more
doaj +1 more source