Results 141 to 150 of about 1,695,081 (360)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effect of the TGF-b signaling pathway on spinal cord ependymoma: A study based on bioinformatics analysis and clinical trials

This study aimed to identify potential therapeutic targets for spinal cord ependymoma (SCE) and key signaling pathways associated with the transforming growth factor b (TGF-b) signaling pathway through bioinformatics analysis, molecular biology ...
Kun Luo, Mamutijiang Muertizha, Man-li Zhu, Yan-dong Fan, Jia-ming Wang   +4 more
core   +1 more source

Development of clinical pathway for mild cognitive impairment and dementia to quantify cost of age-related cognitive disorders in Malaysia [PDF]

, 2014
As the Malaysian population ages, the burden of age-related cognitive disorders such as dementia and Alzheimer’s disease will increase concomitantly.
Salleh, Mohmad, Muhammad Nur, Amrizal, Aljunid, Syed Mohamed, Koris, Roshanim, Yusuf, Suraya, Maimaiti, Namaitijiang, M. Saring, Ahmad Rasidi, Harun, Nazariah Aiza, Shafie, Asrul Akmal, Haron, Sharifah Aizah, Ismail, Normazwana, Drahman, Ismail, Mat Saher, Zanariah, Ahmed, Zafar, Mohamed Nor, Norashidah   +14 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Knowledge-based clinical pathway for medical quality improvement

, 2011
Clinical pathways have been adopted for various diseases in clinical departments for quality improvement as a result of standardization of medical activities in treatment process.
Zhang, Junping, Liu, Kecheng, Kecheng Liu, Li, Weizi, Junping Zhang, Weizi Li, Hongqiao Yang, Yang, Hongqiao   +7 more
core   +1 more source

Impact of a hospital‐wide sepsis pathway on improved quality of care and clinical outcomes in surgical patients at a comprehensive cancer centre [PDF]

, 2019
Alison Hiong, Karin A. Thursky, Georgina Venn, Benjamin W. Teh, Gabrielle M. Haeusler, Megan Crane, Monica A. Slavin, Leon J. Worth   +7 more
openalex   +1 more source

Development and Validity Testing of a Matrix to Evaluate Maturity of Clinical Pathways: A Case Study in Saskatchewan, Canada [PDF]

, 2023
Crystal Lynn Larson, Jason Vanstone, Taysa‐Rhea Mise, Susan Tupper, Gary Groot, Amir Reza Azizian   +5 more
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Evaluating Clinical Pathway Typhoid Fever Monitoring at ABC Hospital Malang [PDF]

, 2018
ABC Hospital has implemented 15 Clinical Pathway, and Typhoid Fever is the most cases that can be served. The inaccuracy of the monitoring report on the implementation of Clinical Pathway has prevented the hospital from taking appropriate actions to ...
Widyaningrum, K. (Kurnia), Rosalina, I. S. (Ika), Hidayat, M. K. (M), Mansur, M. (Muhammad)   +3 more
core  

Derivation of clinical pathways using evidence-based clinical practice guidelines, illustrated by female breast cancer treatment

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2007
Introduction: The use of evidence-based Clinical Practice Guidelines may contribute to the assurance and enhancement of medical services. A practice oriented realisation within a process- and reference-model supports its implementation and acceptance ...
Stausberg, J., Oberhoff, C., Jacobs, B.
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