Results 161 to 170 of about 1,695,081 (360)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Birmingham, West Midlands’ Young Persons’ Physical Activity Pathway: Evaluation Report
The Birmingham, West Midlands’ Young Persons’ Physical Activity Pathway (YPPAP) is a pilot six week behavioural intervention (a physical activity pathway) aimed at increasing physical activity levels in school-aged children in school years 6 and 7 (ages ...
Crone, Diane +3 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The study of exosomes and microvesicles secreted from breast cancer cell lines
, 2013 Exosomes are small secreted vesicles of endocytic origin with a size range of 50-150 nm. They are secreted by many cell types and display multiple biological functions including immune-activation, immune-suppression, antigen presentation, and the ...
Zheng, Ying
core
Construction of emergency nursing pathway for non⁃traumatic chest pain based on HIRAID framework
Huli yanjiuObjectiveTo construct a emergency nursing pathway for non⁃traumatic chest pain based on HIRAID framework.MethodsClinical need was taken as a prerequisite，theoretical framework was taken as the core，and literature research was taken as support，then a ...
CUI Tiantian +3 more
doaj
Variance analysis in a clinical pathway for gynecological laparoscopic surgery
, 2002 会田 拓也 +6 more
openalex +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms [PDF]
, 2019 Maria B. Goncalves +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source