Results 111 to 120 of about 2,650,204 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effect of Coordinating the Outpatient Treatment across Medical Specialities for Patients With Multimorbidity

International Journal of Integrated Care
Introduction: Patients with multimorbidity attend multiple outpatient clinics. We assessed the effects on hospital use of scheduling several outpatient appointments to same-day visits in a multidisciplinary outpatient pathway (MOP).
Cathrine Bell, Charlotte Weiling Appel, Anders Prior, Anne Frølich, Asger Roer Pedersen, Peter Vedsted   +5 more
doaj   +1 more source

Degenerative findings in lumbar spine MRI: an inter-rater reliability study involving three raters

Chiropractic & Manual Therapies, 2020
Background For diagnostic procedures to be clinically useful, they must be reliable. The interpretation of lumbar spine MRI scans is subject to variability and there is a lack of studies where reliability of multiple degenerative pathologies are rated ...
Klaus Doktor, Tue Secher Jensen, Henrik Wulff Christensen, Ulrich Fredberg, Morten Kindt, Eleanor Boyle, Jan Hartvigsen   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Pharmacists as Interprofessional Collaborators and Leaders through Clinical Pathways

Pharmacy, 2018
Pharmacists possess pivotal competencies and expertise in developing clinical pathways (CPs). We present a tertiary care facility experience of pharmacists vis-a-vis interprofessional collaboration for designing and implementing CPs.
Sherine Ismail, Mohamed Osman, Rayf Abulezz, Hani Alhamdan, K. H. Mujtaba Quadri   +4 more
doaj   +1 more source

Brain health clinics – An evolving clinical pathway?

The Journal of Prevention of Alzheimer's Disease
Dementia clinics traditionally focus on diagnosis and post-diagnostic care. Awareness is increasing that attention to risk factors and their prevention also forms a key part of dementia management.To describe our Bristol Brain Health clinic including 1) Clinical pathway 2) Patient population 3) Patient experience 4) Evaluation in line with published ...
Anneka F․ Butters, Jonathan Blackman, Hannah Farouk, Saba Meky, Margaret․ A Newson, Tomas Lemke, Natalie Rosewell, James․ A․ Selwood, Nicholas․ L․ Turner, Elizabeth․ J․ Coulthard, Hilary․ A․ Archer   +10 more
openaire   +3 more sources

Impact of clinical pathways in surgery [PDF]

, 2018
Background: One strategy to reduce the consumption of resources associated to specific procedures is to utilize clinical pathways, in which surgical care is standardized and preset by determination of perioperative in-hospital processes.
Clavien, Pierre-Alain, Dedes, Konstantin, Dindo, Daniel, Hahnloser, Dieter, Müller, Markus, Steiner, Stefan   +5 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI): Validation of Italian Version in Children with Upper Limb Amputation

Children
Background: The Child Amputee Prosthetics Project—Prosthesis Satisfaction Inventory (CAPP-PSI) is a comprehensive instrument designed to measure satisfaction across functionality, aesthetic, and service domains.
Luigino Santecchia, Gessica Della Bella, Francesca Caspi, Paola Luttazi, Lorenzo Pochiero, Fabrizio Taffoni, Giordana Mariani, Marco Gaudenzi, Donatella Valente, Marco Tofani   +9 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source