Extracorporeal Membrane Oxygenation in Refractory Cardiac Arrest: Current Evidence, Clinical Pathways and Future Directions. [PDF]
Life (Basel)Torre DE, Mangino D, Pirri C.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Integrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model. [PDF]
Diagnostics (Basel)Sokolova E +8 more
europepmc +1 more source
Socioeconomic Predictors of Crisis and Clinical Pathways Among People Contacting a Mental Health Crisis Line. [PDF]
Health Serv Insights, 2023 McCarthy M +4 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Medicina y Seguridad del TrabajoDefinir el método de trabajo utilizado en el estudio de la Calidad Asistencial de accidentes de trabajo leves, siguiendo las fases del proceso (estudio del proceso desde su entrada en admisión, la historia clínica, la comunicación entre servicios ...
Carolina Gerónimo Blasco +4 more
doaj
Exploring Clinical Pathways to a Metastatic Lung Cancer Diagnosis: A Latent Class Analysis Using North Carolina Multipayer Claims Data. [PDF]
Cancer Epidemiol Biomarkers PrevCoombs LA +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Capturing the variety of clinical pathways in patients with schizophrenic disorders through state sequences analysis. [PDF]
BMC Med Res Methodol, 2023 Savaré L, Ieva F, Corrao G, Lora A.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source