Results 141 to 150 of about 1,672,515 (266)

Next-Generation Sequencing in Infectious-Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption. [PDF]

Microbiologyopen
Osei Sekyere J.
europepmc   +1 more source

Preliminary research of the clinical pathways of glaucomatous optic nerve damage in cases with glaucomatocyclitic crisis: A retrospective study. [PDF]

Medicine (Baltimore), 2023
Cao D, Hu J, Sun Z, Lei Q, Zhang W, Zhang Y, Zhou H.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Improving Patient-Centred Care and Clinical Pathways: The Role of the Patient Care Radiation Therapist (PCRT). [PDF]

J Med Radiat Sci
Lewis L, Crispin M, Grimberg K, King C, Atyeo J.   +4 more
europepmc   +1 more source

Diagnostic Reasoning of Resident Physicians in the Age of Clinical Pathways. [PDF]

J Grad Med Educ, 2022
Congdon M, Clancy CB, Balmer DF, Anderson H, Muthu N, Bonafide CP, Rasooly IR.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pulmonary Arterial Hypertension and Cancer: Unveiling Parallels in Epidemiology, Clinical Pathways, and Therapeutic Strategies. [PDF]

J Mark Access Health Policy
El-Kersh K, Zawadzki N, Coyle C, Zhang S, Dalal D, Watzker A, Lautsch D, Shafrin J.   +7 more
europepmc   +1 more source

To the Editor: A Response to: Diagnostic Reasoning of Resident Physicians in the Age of Clinical Pathways. [PDF]

J Grad Med Educ, 2022
Kowdley G, Joyner RL, McCutcheon B.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Clinical Pathways in Managing High-Caries Children with Adverse Dental Histories. [PDF]

Medicina (Kaunas)
Hashemi F, Al Masri A, Splieth CH, Schmoeckel J.   +3 more
europepmc   +1 more source