Results 211 to 220 of about 11,531,725 (348)

Clinical Pharmacology Approaches to Predict Efficacy of Monoclonal Antibodies Against Emerging SARS-CoV-2 Variants. [PDF]

Clin Transl Sci
Wang Q, Nader A, Peppercorn A, Skingsley A, Lloyd E, Stella AO, Walker J, Garner C.   +7 more
europepmc   +1 more source

Associations of lifestyle‐related factors and psoriatic arthritis disease activity: the Dutch south west psoriatic arthritis study

Arthritis Care &Research, Accepted Article.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients newly diagnosed with PsA, between 2013 and 2023. A composite lifestyle risk score (range 0 to 5) was calculated using five lifestyle‐
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

Clinical Pharmacology Profile of the Claudin 18.2 Antibody Zolbetuximab. [PDF]

Clin Pharmacokinet
Yang J, Yamada A, Shitara K, Xu RH, Ilson D, Lonardi S, Klempner SJ, Ueno Y, Takeuchi M, Pavese J, Wojtkowski T, Matsangou M, Poondru S.   +12 more
europepmc   +1 more source

Clinical Pharmacology Considerations for the Development of Immune Checkpoint Inhibitors

Journal of clinical pharmacology, 2017
J. Sheng, S. Srivastava, Kinjal Sanghavi, Zheng Lu, B. Schmidt, A. Bello, Manish Gupta   +6 more
semanticscholar   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Evaluation of the Accuracy and Reliability of Responses Generated by Artificial Intelligence Related to Clinical Pharmacology. [PDF]

J Clin Med
Ordak M, Adamczyk J, Oskroba A, Majewski M, Nasierowski T.   +4 more
europepmc   +1 more source

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

How Clinical Pharmacology Can Support Clinical Trial Diversity and Inclusion. [PDF]

Clin Transl Sci
Liao MZ, Sawant A, Corrigan B, Haertter S, Otsubo Y, Younis IR, Kasichayanula S, Mehta R.   +7 more
europepmc   +1 more source

International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors

Pharmacological Reviews, 2017
C. Szabó, A. Papapetropoulos
semanticscholar   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source