Results 241 to 250 of about 9,989,625 (302)

Asia-inclusive drug development leveraging principles of ICH E5 and E17 guidelines: Case studies illustrating quantitative clinical pharmacology as a foundational enabler. [PDF]

Clin Transl Sci
Lu H, Klopp-Schulze L, Mukker JK, Li D, Kuroki Y, Bolleddula J, Terranova N, Goteti K, Gao W, Strotmann R, Dong J, Venkatakrishnan K.   +11 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Clinical pharmacology of antiplatelet drugs

Expert Review of Clinical Pharmacology, 2022
Introduction Platelets play a key role in arterial thrombosis and antiplatelet therapy is pivotal in the treatment of cardiovascular disease. Current antiplatelet drugs target different pathways of platelet activation and show specific pharmacodynamic ...
Georg Gelbenegger, B. Jilma
semanticscholar   +1 more source

Clinical Pharmacology of Cilazapril [PDF]

Drugs, 1989
In clinical pharmacology studies, cilazapril, after its bioactivation to cilazaprilat, was characterised as a potent, reversible angiotensin converting enzyme (ACE) inhibitor with a terminal half-life of 30 to 50 hours, which is consistent with saturable binding to ACE.
Ulf-W. Wiegand, Cornelis H. Kleinbloesem, Robert J. Francis, Peter Van Brummelen   +3 more
openaire   +3 more sources

Clinical Pharmacology

Clinical Pharmacology, 2022
This article has been selected by the Editorial Board of the Hong Kong Medical Diary for participants in the CME programme of the Medical Council of Hong Kong (MCHK) to complete the following self-assessment questions in order to be awarded 1 CME credit ...
Irina Veniaminovna Andreeva, Andrey I. Danilov, Lyudmila Pavlovna Zharkova, R. Kozlov, Sergey Nikolaevich Kozlov, E. V. Khaykina, O. U. Stetsyuk, A. Vertkin, Elena Adamovna Prokhorovich, M. Shamuilova, Elena Ivanovna Vovk, Elena Vitalyevna Sayutina, Yulia Vladimirovna Sedyakina, Elena Gennadievna Silina, Anna Vladimirovna Nosova, Anastasia Leonidovna Kebina, S. S. Kurdzhieva, German Yuryevich Knorring, Aleksandra Sergeyevna Sycheva, V. V. Rafalsky, S. A. Rachina, Konstantin Andreevich Sedyakin   +21 more
semanticscholar   +1 more source

American College of Clinical Pharmacology Response to the Institute of Medicine Report “To Err Is Human: Building a Safer Health System”

Journal of clinical pharmacology, 2000
The public press is laden with articles describing serious errors in medical care and treatment that are associated with increased morbidity and mortality.

semanticscholar   +1 more source

An update on the clinical pharmacology of methylphenidate: therapeutic efficacy, abuse potential and future considerations

Expert Review of Clinical Pharmacology, 2020
Introduction Methylphenidate remains a first-line medication for treating ADHD in children and adults. However, its behavioral pharmacological similarities to methamphetamine and cocaine have historically created concern for its potential as a drug of ...
Thomas P. Shellenberg, William W. Stoops, J. Lile, C. Rush   +3 more
semanticscholar   +1 more source

Pharmacology and Clinical Pharmacology of Vigabatrin [PDF]

Journal of Child Neurology, 1991
Vigabatrin is an enzyme-activated, irreversible inhibitor of γ-aminobutyric acid (GABA) aminotransferase, which causes a marked increase in cerebral GABA concentration and a resulting anticonvulsant action. Recovery from its effects requires the synthesis of new enzyme, and this may take several days following a single dose.
openaire   +2 more sources

Clinical Pharmacology

DeckerMed Surgery, 2020
Critically ill patients often require surgical procedures and therapeutic interventions that produce significant pathophysiologic changes. Drug pharmacology can be greatly altered in this population wherein comorbid diseases, varied organ function, and polypharmacy can produce adverse drug reactions (ADRs).
Eric W. Mueller, Molly Droege
openaire   +1 more source

Clinical pharmacology of progestins

Minerva Obstetrics and Gynecology, 2022
In this paper, we report general pharmacological profile and major biological activities of natural progesterone (P) and progestins. The aim of this article consists of synthesizing the principal aspects of pharmacology and metabolism of P and progestins related to the clinical consequences of their use.We review scientific literature on the topic ...
Capozzi, Anna, Scambia, Giovanni, Lello, Stefano   +2 more
openaire   +3 more sources

Clinical Pharmacology

JAMA: The Journal of the American Medical Association, 1989
The issue of what drug effects to measure, surrogate end points, has been emphasized by two recent clinical trials. Several recent studies have given us new information about why different people react so differently to the same dose of the same medicine.
openaire   +5 more sources