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Agents for Change: Artificial Intelligent Workflows for Quantitative Clinical Pharmacology and Translational Sciences. [PDF]
Clin Transl SciShahin MH +3 more
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Abstracts 3rd Annual Congress on Clinical Pharmacology : 15 - 17 November 2001, Cologne, Germany
, 2001 Verbund Klinische Pharmakologie in Deutschland +1 more
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Clinical Pharmacology of Cilazapril
Drugs, 1989In clinical pharmacology studies, cilazapril, after its bioactivation to cilazaprilat, was characterised as a potent, reversible angiotensin converting enzyme (ACE) inhibitor with a terminal half-life of 30 to 50 hours, which is consistent with saturable binding to ACE.
C H, Kleinbloesem +3 more
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Clinical Pharmacology of Inodilators
Journal of Cardiovascular Pharmacology, 1989Recent advances in our knowledge of heart failure have shown that both a central and a peripheral factor are involved in this syndrome. Therefore, the ideal drug should combine the properties of a positive inotropic agent with those of a peripheral vasodilator; many drugs recently introduced into clinical practice have been shown to present both of ...
DEI CAS, Livio +2 more
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The chemistry, pharmacology and clinical pharmacology of diflunisal
Current Medical Research and Opinion, 1978Studies are reviewed on diflunisal, a new analgesic agent with an improved therapeutic index, compared with acetylsalicylic acid, in animals and humans. Pharmacokinetic data indicate that a twice-daily dosage regimen of diflunisal is adequate for therapeutic purposes.
S L, Steelman +2 more
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JAMA: The Journal of the American Medical Association, 1989
The issue of what drug effects to measure, surrogate end points, has been emphasized by two recent clinical trials. Several recent studies have given us new information about why different people react so differently to the same dose of the same medicine.
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The issue of what drug effects to measure, surrogate end points, has been emphasized by two recent clinical trials. Several recent studies have given us new information about why different people react so differently to the same dose of the same medicine.
openaire +5 more sources
Clinical pharmacology of progestins
Minerva Obstetrics and Gynecology, 2022In this paper, we report general pharmacological profile and major biological activities of natural progesterone (P) and progestins. The aim of this article consists of synthesizing the principal aspects of pharmacology and metabolism of P and progestins related to the clinical consequences of their use.We review scientific literature on the topic ...
Capozzi, Anna +2 more
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Clinical pharmacology and malaria
Annals of Tropical Medicine And Parasitology, 1997The role of clinical pharmacology in improving the prevention and treatment of malaria is reviewed. A series of general and specific issues is discussed, concentrating on risk-benefit and cost-effectiveness. The techniques of clinical pharmacokinetics play an important role in the optimal use of drugs and this is illustrated by studies on quinine and ...
A M, Breckenridge, P A, Winstanley
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The clinical pharmacology of eplerenone
Expert Opinion on Drug Metabolism & Toxicology, 2009Eplerenone is an aldosterone receptor antagonist indicated for the treatment of hypertension and congestive heart failure. Eplerenone contains an epoxy group, which offers greater mineralocorticoid receptor specificity. It is an effective antihypertensive that has been shown to reduce morbidity and mortality in individuals with left ventricular ...
James A, Muldowney +2 more
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