Results 241 to 250 of about 519,368 (313)

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Clinical Pharmacology of Bulevirtide: Focus on Known and Potential Drug-Drug Interactions. [PDF]

Pharmaceutics
Billi M, Soloperto S, Bonora S, D'Avolio A, De Nicolò A.   +4 more
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Clinical Pharmacology Overview of Tislelizumab in Patients With Advanced Tumors With a Focus on Racial Impact. [PDF]

Clin Transl Sci
Yu T, Wu CY, Sahasranaman S, Tian X, Fei Li Y, Tang Z, Yang Y, Wan Y, Zhang Q, Schnell P, Mendoza-Naranjo A, Abdrashitov R, Hanley WD, Budha N.   +13 more
europepmc   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

The Edges of Clinical Pharmacology: A Narrative Review on Religious and Sociocultural Influences in Drug Management. [PDF]

Clin Transl Sci
Di Maria S, Provenzani A.
europepmc   +1 more source

The Finite Absorption Time Concept Guiding Model Informed Drug & Generics Development in Clinical Pharmacology. [PDF]

Pharm Res
Macheras P, Tsekouras AA, Sánchez-Herrero S, Kosmidis K.   +3 more
europepmc   +1 more source

Clinical pharmacology in adolescent transgender medicine. [PDF]

Br J Clin Pharmacol
Cirrincione LR, Huang KJ, Sequeira GM.
europepmc   +1 more source

Recommended Phase II Doses of Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma From MonumenTAL-1: Clinical Pharmacology Results. [PDF]

Clin Pharmacol Ther
Gong J, Zhou J, Yuan D, Ma X, Vishwamitra D, Hilder B, Masterson TJ, Tolbert J, Renaud T, Heuck C, Kane C, Samtani MN, Girgis S, Haddish-Berhane N, Berdeja J, Krishnan A, Ouellet D.   +16 more
europepmc   +1 more source

AI-Driven Applications in Clinical Pharmacology and Translational Science: Insights From the ASCPT 2024 AI Preconference. [PDF]

Clin Transl Sci
Shahin MH, Desai P, Terranova N, Guan Y, Helikar T, Lobentanzer S, Liu Q, Lu J, Madhavan S, Mo G, Musuamba FT, Podichetty JT, Shen J, Xie L, Wiens M, Musante CJ.   +15 more
europepmc   +1 more source