Results 301 to 310 of about 9,870,305 (401)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Computational and Experimental Analysis of Drug‐Coated Microneedle Skin Insertion: The Mode of Administration Matters

Advanced Materials Interfaces, EarlyView.
This study investigates how the mode of application affects drug delivery from coated microneedles. Combining finite element modeling with custom 3D‐printed Franz Diffusion Cells, the researchers found that prolonged application pressure from microneedles in situ reduces drug permeation.
Wenting Shu, Thomas Lijnse, Fiona McCartney, David J. Brayden, Aisling Ní Annaidh, Eoin D. O'Cearbhaill   +5 more
wiley   +1 more source

Editorial: Advanced approaches in pediatric clinical pharmacology. [PDF]

Front Pharmacol
Al-Sallami H, Diniz A, Sinha J, Karatza E, Allegaert K.   +4 more
europepmc   +1 more source

Bioengineered Models of Nerve Regeneration

Advanced Materials Technologies, EarlyView.
Bioengineered nerve regeneration platforms ranging from patterned cell cultures and hydrogels to fibrous scaffolds and microfluidic systems are reviewed, highlighting the complex cellular and biochemical environments essential for nerve repair. Challenges associated with these platforms, such as balancing complexity with throughput and the need for ...
Madalynn Jade Thompson, John Paul Frampton   +1 more
wiley   +1 more source

Clinical pharmacology of 2, 3-dichloro-4-methoxyphenyl 2-furyl ketone (E)-0- [2-(diethylamino) ethyl] oxime (ANP 4364) in healthy volunteers

, 1979
Mitsuyoshi Nakashima, Kunifumi Suzuki, Hisakuni Hashimoto, Katsunori Oguro, Kenji Nishijima   +4 more
openalex   +2 more sources

The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation. [PDF]

PLoS Negl Trop Dis
Wood ND, Smith D, Kinrade SA, Sullivan MT, Rayner CR, Wesche D, Patel K, Rowland-Yeo K.   +7 more
europepmc   +1 more source

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source

Clinical pharmacological studies on serum dopamine β-hydroxylase

, 1978
Miyako Baba, Kazuo Sawami, Tadao Itoh, S. Yoshida   +3 more
openalex   +1 more source

Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease. [PDF]

Clin Pharmacol Drug Dev
Rolan P, Seckl J, Taylor J, Harrison J, Maruff P, Woodward M, Mills R, Jaros M, Hilt D.   +8 more
europepmc   +1 more source

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

Advanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen, Libing Huang, Lei Ren, Miao Wang   +3 more
wiley   +1 more source