Results 81 to 90 of about 11,531,725 (348)
Kratom—Pharmacology, Clinical Implications, and Outlook: A Comprehensive Review
Pain and Therapy, 2020 Kratom, or Mitragyna , is a tropical plant indigenous to Southeast Asia, with unique pharmacological properties. It is commonly consumed by preparing the leaves into decoction or tea, or by grinding them into a powder.
Steven C Eastlack, E. Cornett, A. Kaye
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
AntibodiesThe objective of this work was to develop a population physiologically based pharmacokinetic (popPBPK) model to characterize the variability in the clinical PK of monoclonal antibodies (mAbs) following intravenous (IV) and subcutaneous (SC ...
Mokshada Kumar +5 more
doaj +1 more source
Clinical Pharmacology in the UK, c.1950-2000: Industry and Regulation [PDF]
, 2008 Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.First published by the Wellcome Trust Centre for the ...
Reynolds, LA, Tansey, EM
core
Process Improvement for Maximized Therapeutic Innovation Outcome. [PDF]
, 2017 Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients ...
Terzic, Andre, Waldman, Scott A.
core +2 more sources
Basic & Clinical Pharmacology & Toxicology Policy for Experimental and Clinical studies.
Basic & Clinical Pharmacology & Toxicology, 2018 Inconsistencies in the reproducibility of research findings are of pertinent concern throughout the scientific community. Initially addressed in preclinical biomedicine studies [1, 2], the discussion has expanded to fields outside the natural sciences ...
P. Tveden‐Nyborg +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in Medicine, 2020 Objective: To assess polypharmacy and related medication aspects in Middle-European rheumatoid arthritis (RA) patients, and to discuss the results in view of a systematic literature review.Methods: In this retrospective cohort study, charts were reviewed
Jacqueline Désirée Jack +3 more
doaj +1 more source
Filmed clinical cases improved communication skills of student of Pharmacology in Podiatry degree [PDF]
, 2015 Solving clinical case by writing-report lacks of students sympathies and interest in many cases. Make a short film is a novelty that really like to the students and may improve their arguing and planning capacities and their communication skills.
Bellido-Estevez, Inmaculada +5 more
core
The effect of weight, body mass index, age, sex, and race on plasma concentrations of subcutaneous sumatriptan: a pooled analysis. [PDF]
, 2016 Objective/backgroundFactors such as body size (weight and body mass index [BMI]), age, sex, and race might influence the clinical response to sumatriptan. We evaluated the impact of these covariates on the plasma concentration (Cp) profile of sumatriptan
Fisher, Dennis M +3 more
core +3 more sources