Results 81 to 90 of about 519,368 (313)
Drug Design, Development and TherapyRobert Kleiman,1 Todd Rudo,1 William Daley,2 Mengyue Hu,3 Pangke Yan,3 Rong Zhou,3 Jie Hou4 1Cardia Safety, Clario, Philadelphia, PA, USA; 2Haisco-USA Pharmaceutical Company, Inc, Bridgewater, NJ, USA; 3Haisco Pharmaceutical Group Co.
Kleiman R +6 more
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
, 2013 The use of complementary and alternative medicines (CAM), such as herbs and dietary supplements, has become more popular among cancer patients. Cancer patients use these supplements for different reasons such as reduction of side effects and improvement ...
Clinical Pharmacology +2 more
core
Journal of Integrated Health SciencesThe convergence of family medicine and clinical pharmacology signifies a vital evolution in modern healthcare, particularly in the era of chronic diseases, polypharmacy, and rising healthcare expenditures.
SK Sabir Rahaman
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Clinical Pharmacology of Kinase Inhibitors in Oncology: Personalized and Optimzed Dosing
, 2017 Kinase inhibitors are an important category of molecularly targeted therapies used for cancer. Verheijen’s doctoral thesis describes several clinical pharmacological studies to optimize and personalize the treatment of cancer with kinase inhibitors ...
Verheijen, Remy B. +1 more
core
Clinical pharmacology = disease progression + drug action.
, 2015 Clinical pharmacology is concerned with understanding how to use medicines to treat disease. Pharmacokinetics and pharmacodynamics have provided powerful methodologies for describing the time course of concentration and effect in individuals and in ...
Holford, Nicholas
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
British Journal of Clinical Pharmacology
The British Journal of Clinical Pharmacology (BJCP) contains papers and reports on all aspects of drug action in humans: invited review articles, original papers and correspondence.
Borghi C
core +1 more source
Swiss Medical Weekly, 2012 QUESTIONS UNDER STUDY/PRINCIPLES: Data regarding the prevalence and types of drug-related problems (DRPs) among neurology inpatients is sparse. The objective of this study was to characterise the types of DRPs seen among neurology inpatients and ...
Anne B Taegtmeyer +8 more
doaj +1 more source