Results 101 to 110 of about 519,368 (313)

The journal of clinical pharmacology.

Voortzetting van: Journal of clinical pharmacology and new ...
American college of clinical pharmacology
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Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Clinical‐Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022–2024)

Pharmacology Research & Perspectives
Drug information centers (DICs) are institutions dedicated to providing independent and up‐to‐date information on medications and their usage to healthcare professionals.
Johannes Heck, Dirk O. Stichtenoth, Christoph Schröder, Ruxandra Sabau, Anna‐Leena K. Heim, Felix Koop, Thorben Pape, Sebastian Schröder, Martin Schulze Westhoff, Benjamin Krichevsky, Martin Klietz, Stephan Greten, Carsten Schumacher   +12 more
doaj   +1 more source

An account on the history of pharmacology in Spain

Pharmacological Research
Here we present an account on the history of pharmacology in Spain. Pharmacology as an independent science in Europe began with the creation of university chairs.
Ana María Aldea-Perona, Jesús Flórez Beledo, Jesús Frías Iniesta, Antonio G. García, Juan Tamargo, Francisco Zaragozá   +5 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Safety Profile of Non-Steroidal Anti-Inflammatory Drugs in Clinical Practice: New Insights from Electronic Health Care and Spontaneous Reporting Databases

, 2019
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat condition with pain, inflammation, and/or fever. The relative inhibitory potency towards cyclooxygenase (COX) enzymes and the chemical groups of NSAIDs, including the presence or ...
Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Bakhriansyah, Mohammad   +2 more
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P-gp and taxanes

, 2014
In the past years, the development of oral formulations of the taxane anticancer drugs paclitaxel (Taxol®) and docetaxel (Taxotere®) has been the focus of preclinical and clinical research in our groups.
Hendrikx, Jeroen J M A, Pharmacoepidemiology and Clinical Pharmacology, Schinkel, Alfred H, Sub Clinical Pharmacology, Beijnen, Jos H   +4 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study

, 2019
Galunisertib is an anti-cancer drug currently evaluated in phase I and II clinical trials. This study describes the development and validation of a bioanalytical assay to quantify galunisertib in human plasma using HPLC-MS/MS.
Huijberts, S, Afd Pharmacoepi & Clinical Pharmacology, Schinkel, A H, Pharmacoepidemiology and Clinical Pharmacology, Beijnen, J H, Li, W, Gebretensae, A, Tibben, M M, Rosing, H   +8 more
core   +1 more source

Phytopharmacology: at the origins of pharmacy and clinical pharmacology

Фармакокинетика и Фармакодинамика, 2014
Article is devoted to historical review of pharmacology and pharmacy herbal medicines since ancient times.
D. A. Sychev, K. V. Gerasimov, D. U. Belousov   +2 more
doaj