Results 121 to 130 of about 519,368 (313)
Evaluation and management of side effects of breast cancer treatment
, 2011 Breast cancer is one of the most common malignant diseases. Adjuvant systemic therapies such as chemotherapy, immunotherapy and endocrine therapy play an important role in the treatment of breast cancer.
Clinical Pharmacology +3 more
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
A textbook of clinical pharmacology and therapeutics.
, 2008 Previous edition: published as A textbook of clinical pharmacology by James M. Ritter, Lionel D. Lewis, Timothy G.K. Mant. New York; London: Arnold, 1999.Includes bibliographical references and index.465 pages :Fully revised throughout and extensively ...
Ritter, James. +1 more
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, 2020 The development of new drugs to treat cancer has increased significantly over the past years. Many of the newly developed targeted drugs are administered orally, causing an increased variability in drug levels and exposure compared to intravenously ...
Pharmacoepidemiology and Clinical Pharmacology +1 more
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Large Language Models and Their Applications in Drug Discovery and Development: A Primer
Clinical and Translational ScienceLarge language models (LLMs) have emerged as powerful tools in many fields, including clinical pharmacology and translational medicine. This paper aims to provide a comprehensive primer on the applications of LLMs to these disciplines.
James Lu +8 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
, 2018 When conducting health technology assessments (HTA) to reach decisions on the reimbursement of health interventions, HTA agencies often resort to scientific evidence of the highest degree available; thus conventionally randomized controlled clinical ...
Makady, A.A.M.A. +2 more
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Advances in Medical Education and Practice, 2014 Joseph P Kitzmiller,1,4 Mitch A Phelps,2 Marjorie V Neidecker,3 Glen Apseloff41Center for Pharmacogenomics, Colleges of Medicine and of Engineering, The Ohio State University Medical Center, 2Colleges of Pharmacy and Medicine, Pharmacoanalytic Shared ...
Kitzmiller JP +3 more
doaj