Results 111 to 120 of about 519,368 (313)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review

, 2019
BACKGROUND: Recently, two phase II trials showed intracranial activity of the immune checkpoint inhibitors nivolumab and ipilimumab in patients with melanoma brain metastases.
van Bussel, Mark T J, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Brandsma, Dieta, Beijnen, Jos H   +4 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Antineoplastic drugs in veterinary oncology: excretion in dogs, contamination of the environment and exposure assessment of people at risk

, 2012
Anticancer drugs themselves can cause adverse health effects when administered to human patients. In addition, it has become apparent that personnel in human medicine, occupationally exposed to these anticancer drugs, may also be at risk.
Clinical Pharmacology, Janssens, T., Sub Clinical Pharmacology   +2 more
core  

Pharmacoeconomics as an instrument of clinical pharmacology for optimization of pharmacotherapy (review)

Регуляторные исследования и экспертиза лекарственных средств, 2018
Pharmacoeconomics is an essential component of health technology assessment and the appraisal of medicines for use by patients. As a comparatively young discipline, its methods continue to evolve.
O. V. Reshet'ko, K. A. Lutsevich
doaj  

Awareness of Geriatric Services among North Indian Graduate Medical Students – Insights for Planning Training in Geriatric Medicine

Journal of the Indian Academy of Geriatrics
Background: The older population is rapidly increasing in India. We aimed to understand the perception of graduate medical students toward geriatric medicine services, which might aid in future geriatric curriculum planning.
Zeba Fatima, Telagamsetti Sesha Sai Lahari, Aditi Pandey, Sankha Shubhra Chakrabarti, Upinder Kaur   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Small animal clinical pharmacology /

Revised edition of: Small animal clinical pharmacology / Jill E. Maddison, Stephen W. Page, David Church. 2002.Includes bibliographical references and index.Principles of clinical pharmacology / Stephen W. Page and Jill E.
Maddison, Jill E.,editor., Page, Stephen W.,editor., Church, David B.,editor.   +2 more
core  

Treatment optimization of fluoropyrimidines as single agent and in combination therapy

, 2011
Fluoropyrimidines, including 5-fluorouracil (5-FU) and its oral prodrugs capecitabine and tegafur, are among the most commonly prescribed anticancer drugs for the adjuvant and palliative treatment of various types of solid malignancies, including ...
Pharmacoepidemiology, Clinical Pharmacology, Deenen, MJ, Sub Clinical Pharmacology   +3 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source