Results 81 to 90 of about 9,321,832 (392)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight [PDF]

open access: yesNature Microgravity 5:15 (2019), 2019
As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight.
arxiv   +1 more source

Evolution of Preprofessional Pharmacy Curricula [PDF]

open access: yes, 2013
Objectives. To examine changes in preprofessional pharmacy curricular requirements and trends, and determine rationales for and implications of modifications. Methods.
Birnie, Christine R.   +5 more
core   +2 more sources

Physicians’ perspectives on clinical pharmacy services in Northern Sweden: a qualitative study

open access: yesBMC Health Services Research, 2018
BackgroundIn many countries, clinical pharmacists are part of health care teams that work to optimize drug therapy and ensure patient safety. However, in Sweden, clinical pharmacy services (CPSs) in hospital settings have not been widely implemented and ...
Charlotta Vinterflod   +3 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Identifying roles of clinical pharmacy with survey evaluation [PDF]

open access: yesarXiv, 2014
The survey data sets are important sources of data and their successful exploitation is of key importance for informed policy-decision making. We present how a survey analysis approach initially developed for customer satisfaction research in marketing can be adapted for the introduction of clinical pharmacy services into hospital.
arxiv  

Human-machine cooperation: optimization of drug retrieval sequencing in automated drug dispensing systems [PDF]

open access: yesarXiv, 2023
Automated drug dispensing systems (ADDSs) are increasingly in demand in today's pharmacies, primarily driven by the growing ageing population. Recognizing the practical challenges faced by pharmacies implementing ADDSs, this study aims to optimize the layout design and sequencing issues within a human-machine cooperation environment to enhance the ...
arxiv  

Challenges and opportunities of clinical pharmacy services in Ethiopia: A qualitative study from healthcare practitioners’ perspective

open access: yesPharmacy in practice, 2018
Background: Currently, clinical pharmacists have in-depth therapeutic knowledge and scientific skills to act as drug therapy experts in healthcare settings.
H. Tegegn   +4 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

The impact of pharmacybernetic in reducing medication error [PDF]

open access: yesarXiv, 2012
Doctors and Pharmacists play a foremost role in safe, effective use of medication in health care. Still, there is no database available through which Doctor can communicate with all field of pharmacy such as hospital Pharmacy, Clinical Pharmacy, Community Pharmacy, Nutrition Pharmacy and Drug research center so that they would like to cooperate with ...
arxiv  

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