Results 81 to 90 of about 836,001 (298)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting [PDF]

, 2019
Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians ...
Avery, Lisa M., Bookstaver, P. Brandon, Justo, Julie Ann, Kufel, Wesley D.   +3 more
core   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The Impact of a Training Program on Clinical Pharmacists on Pharmacy Clinical Services in a Tertiary Hospital in Hunan China

Journal of Multidisciplinary Healthcare, 2019
Ping Xu,1 Yi Yun Hu,1 Hai Yan Yuan,1 Da Xiong Xiang,1 Yan Gang Zhou,1 Andrew J Cave,2 Hoan Linh Banh2 1Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410008, People’s Republic of China; 2Department ...
Xu P, Hu YY, Yuan HY, Xiang DX, Zhou YG, Cave AJ, Banh HL   +6 more
doaj  

ChatGPT and Clinical Training: Perception, Concerns, and Practice of Pharm-D Students

Journal of Multidisciplinary Healthcare, 2023
Mohammed Zawiah,1,2 Fahmi Y Al-Ashwal,3 Lobna Gharaibeh,4 Rana Abu Farha,5 Karem H Alzoubi,6,7 Khawla Abu Hammour,8 Qutaiba A Qasim,3 Fahd Abrah9 1Department of Clinical Pharmacy, College of Pharmacy, Northern Border University, Rafha, 91911, Saudi ...
Zawiah M, Al-Ashwal FY, Gharaibeh L, Abu Farha R, Alzoubi KH, Abu Hammour K, Qasim QA, Abrah F   +7 more
doaj  

Clinical pharmacy practice in developing countries: Focus on India and Pakistan

Archives of Pharmacy Practice, 2014
Clinical pharmacy practice is undergoing unprecedented changes as standard profession of pharmacy practice by means of pharmaceutical care. Although, the clinical pharmacy is well recognized in developed countries, but the implementation of clinical ...
Akshaya Srikanth Bhagavathula, Barun Ranjan Sarkar, Isha Patel   +2 more
doaj   +1 more source

Self-assessment in the implementation of pharmaceutical care in Indonesian hospitals [PDF]

, 2018
— Background: Pharmaceutical care is regarded as the process of optimizing the outcome of a patient’s drug therapy, thus improving the patient’s quality of life.
Setiadi, Antonius Adji Prayitno, Wardani, Susilo Ari, Wibowo, Ika Mulyono Putri, Wibowo, Yosi Irawati   +3 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source