Results 91 to 100 of about 15,514,333 (343)

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

European Heart Journal, 2021
F. Visseren, F. Mach, Y. Smulders, D. Carballo, K. Koskinas, Maria Bäck, A. Benetos, A. Biffi, J. Boavida, D. Capodanno, B. Cosyns, Carolyn B Crawford, C. Davos, I. Desormais, E. Angelantonio, O. Franco, S. Halvorsen, F. R. Hobbs, M. Hollander, E. Jankowska, M. Michal, Simona Sacco, N. Sattar, L. Tokgozoglu, S. Tonstad, K. Tsioufis, I. V. Dis, I. C. Gelder, C. Wanner, B. Williams, G. D. Backer, V. Regitz-Zagrosek, A. Aamodt, M. Abdelhamid, V. Aboyans, C. Albus, R. Asteggiano, Magnus Bäck, M. Borger, C. Brotons, J. Čelutkienė, R. Cífková, M. Čikeš, F. Cosentino, N. Dagres, T. D. Backer, D. Bacquer, V. Delgado, H. Ruijter, P. Dendale, H. Drexel, V. Falk, L. Fauchier, B. Ference, J. Ferrières, M. Ferrini, M. Fisher, D. Fliser, Z. Fras, D. Gaita, S. Giampaoli, S. Gielen, I. Graham, C. Jennings, T. Jørgensen, A. Kautzky-Willer, M. Kavousi, W. Koenig, A. Konradi, D. Kotecha, U. Landmesser, Madalena Lettino, B. Lewis, A. Linhart, M. Løchen, K. Makrilakis, G. Mancia, P. Marques-Vidal, J. McEvoy, Paul McGreavy, B. Merkely, L. Neubeck, J. Nielsen, J. Perk, Steffen E Petersen, A. Petronio, M. Piepoli, N. Pogosova, E. Prescott, K. Ray, Ž. Reiner, D. Richter, L. Rydén, E. Shlyakhto, M. Sitges, M. Sousa‐Uva, I. Sudano, M. Tiberi, R. Touyz, A. Ungar, W. Verschuren, O. Wiklund, D. Wood, J. Zamorano, Carolyn A Crawford, Oscar Durán   +105 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia

Translational Psychiatry
Schizophrenia (SZ) is a deleterious brain disorder characterised by its heterogeneity and complex symptomatology consisting of positive, negative and cognitive deficits.
David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó   +6 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Data Resource Profile: Clinical Practice Research Datalink (CPRD)

International Journal of Epidemiology, 2015
The Clinical Practice Research Datalink (CPRD) is an ongoing primary care database of anonymised medical records from general practitioners, with coverage of over 11.3 million patients from 674 practices in the UK.
E. Herrett, A. Gallagher, K. Bhaskaran, H. Forbes, R. Mathur, T. V. van Staa, L. Smeeth   +6 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Self-medication and self-prescription with antibiotics in the Middle East—do they really happen? A systematic review of the prevalence, possible reasons, and outcomes

International Journal of Infectious Diseases, 2017
Objectives: There has been no review on the prevalence, possible causes, and clinical outcomes of self-medication with antibiotics (SMA) in the Middle East.
Faten Alhomoud, Zainab Aljamea, Reem Almahasnah, Khawlah Alkhalifah, Lama Basalelah, Farah Kais Alhomoud   +5 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Clinical Urology for General Practice [PDF]

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openalex   +2 more sources