Results 101 to 110 of about 18,067,200 (315)

Knowledge and attitude of human Mpox viral infection among pharmacy students in Jazan University: a web based cross-sectional study

Frontiers in Public Health
IntroductionSaudi Arabia has witnessed the first confirmed case of Mpox on July 14th, 2022. Currently, there is no approved medication for the treatment of this infection. Therefore, prevention of this infection is crucial.
Eman Merghani Ali, Eman Merghani Ali, Amani Khardali, Amani Khardali, Nawazish Alam, Nawazish Alam, Abdulkarim M. Meraya, Abdulkarim M. Meraya, Hilal A. Thaibah, Hilal A. Thaibah, Dalin A. Hassan, Mohamed Eltaib Elmobark, Alanood Aladwani, Alanood Aladwani, Anugeetha Thacheril Mohanan, Hanan A. Bakri, Zamzam O. Mashraqi, Areej Mousa Salhabi   +17 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia

Translational Psychiatry
Schizophrenia (SZ) is a deleterious brain disorder characterised by its heterogeneity and complex symptomatology consisting of positive, negative and cognitive deficits.
David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Anemia in heart failure: evidence from a three-year cross-sectional study in Sudan

Journal of Pharmaceutical Health Care and Sciences
Background Anemia is a frequent complication of heart failure (HF) that exacerbates cardiac dysfunction and worsens prognosis. However, its exact burden and treatment patterns in Sudan HF remain unknown. Thus, this study aimed to describe the prevalence,
Maram M. Elamin, Rayan Hafiz Mohamed, Mohamed Alzaki Ahmed, Mugahed Ahmed Abdullah, Afraah Altahir Abdalrahim, Gheida Alamin Elbushra, Yousif B. Hamdalneel, Kannan O. Ahmed   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Health Professions Students as Emerging Leaders: An Appreciative Inquiry into Leadership Experiences and Aspirations at Qatar University

Journal of Healthcare Leadership
Dhabya Mohamed Al-Khater,1,2 Myriam Jaam,1 Menatallah Rayan,1 Derek Stewart,1 Mohammad Issam Diab,2 Alla El-Awaisi1 1Clinical Pharmacy and Practice Department, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Hamad Medical Corporation ...
Al-Khater DM, Jaam M, Rayan M, Stewart D, Diab MI, El-Awaisi A   +5 more
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source