Results 121 to 130 of about 5,045,272 (312)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Immersion in Physiology Bolsters Bedside Mechanistic Thinking [PDF]

, 2019
Purpose and Background: Compression of education and training with other responsibilities into more limited work hours Shift towards algorithm-based teaching/practice Less time spent in practice of basic science Intellectual Curiosity/Mechanistic ...
Miller, Rebecca
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Gifts in Psychotherapy: Practice Review and Recommendations [PDF]

, 2008
The presentation of gifts in psychotherapy, whether to or from the therapist, does not happen frequently, but its occurrence may nevertheless be quite provocative.
Knox, Sarah
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Behavioral Determinants of Leadership Engagement in Health Profession Students: A Cross-Sectional Study Using the Theoretical Domains Framework (TDF)

Journal of Healthcare Leadership
Alla El-Awaisi,1 Menatallah Rayan,1 Dhabya Mohamed Al-Khater,2 Derek Stewart,1 Mohammed Al-Hamdani,3 Myriam Jaam,1 Mohammad Issam Diab1 1Clinical Pharmacy and Practice Department, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Hamad ...
El-Awaisi A, Rayan M, Al-Khater DM, Stewart D, Al-Hamdani M, Jaam M, Diab MI   +6 more
doaj  

Role of Physical Therapists in the Management of Individuals at Risk for or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline [PDF]

, 2016
The American Physical Therapy Association (APTA), in conjunction with the Cardiovascular & Pulmonary and Acute Care sections of APTA, have developed this clinical practice guideline to assist physical therapists in their decision-making process when ...
Auten, Beth, Frese, Ethel M., Hillegass, Ellen, Puthoff, Michael, Sobush, Dennis, Thigpen, Mary   +5 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Ultrasound education, competencies and expected future use among medical interns in Denmark: a national cross-sectional study

BMC Medical Education
Background Point-of-care ultrasound is increasingly used across medical specialties, calling for timely and relevant ultrasound education in specialty training.
Pernille Gram, Thomas Purup, Emilie Marie Eriksen, Stina Søbye, Simone Kjaergaard Wielandt, Kasper Astorp, Martin Bach Jensen, Camilla Aakjaer Andersen   +7 more
doaj   +1 more source

Hypothyroidism in clinical practice

Journal of Family Medicine and Primary Care, 2014
Hypothyroidism is the most common endocrine disease that was seen in the clinical practice especially for family physicians.This review article covered the important practical clinical issues for managing overt hypothyroidism, subclinical hypothyroidism and hypothyroidism during pregnancy.The clinical issues were addressed by clinical scenario followed
openaire   +3 more sources