Results 131 to 140 of about 5,045,272 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Clinical Practice Guidelines: Principles for Clinical Practice

Indian Journal of Psychiatry, 2017
Rao, T.S. Sathyanarayana, Tandon, Abhinav   +1 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Daptomycin Dosing Based on Adjusted Body Weight in Obese Patients versus Actual Body Weight: A Multicentre Cohort Study

Infection and Drug Resistance
Thamer A Almangour,1 Latifa S Almosabhi,2 Rahaf Almojel,1 Rawabi Althubaity,1 Sara Almuhisen,3 Abdullah Almohaizeie,4,5 Shuroug A Alowais,6– 8 Khalid Bin Saleh,6– 8 Nader Damfu,7,9,10 Sultan N Alotaibi,7,10,11 Namareq F Aldardeer,12 Haifa Alotaibi,4 ...
Almangour TA, Almosabhi LS, Almojel R, Althubaity R, Almuhisen S, Almohaizeie A, Alowais SA, Bin Saleh K, Damfu N, Alotaibi SN, Aldardeer NF, Alotaibi H, Alghamdi AA, Almuzaini M, Alyousef A, Alnehari F, Youssef SA, Alharbi MH, Al Musawa M, Alsowaida YS   +19 more
doaj  

Clinical Practice/Education Exchange: Bridging the Theory-Practice Gap

Nursing Praxis in Aotearoa New Zealand, 2002
Nursing education is directed toward development of nursing practitioners competent to nurse effectively in the reality of our present society. A major challenge to the nursing profession is to find ways of merging theory and practice in the delivery of ...
Robyn Brasell-Brian, Esther Vallance
doaj  

Healthcare activities before familial hypercholesterolemia diagnosis: a nationwide register-based study in Denmark

BMC Primary Care
Background Familial hypercholesterolemia is a common yet underdiagnosed genetic disorder that significantly increases the risk of premature atherosclerotic cardiovascular disease.
Simon Graff, Kirsten Høj, Bo Christensen, Flemming Bro, Helle Lynge Kanstrup, Henrik Schou Pedersen   +5 more
doaj   +1 more source

Association between quality of clinical practice guidelines and citations given to their references

, 2013
It has been suggested that bibliometric analysis of different document types may reveal new aspects of research performance. In medical research a number of study types play different roles in the research process and it has been shown, that the evidence-
Andersen, Jens Peter
core  

A pilot study of operating department practitioners undertaking high-risk learning: a comparison of experiential, part-task and hi-fidelity simulation teaching methods [PDF]

, 2016
Health care learners commonly rely on opportunistic experiential learning in clinical placements in order to develop cognitive and psychomotor clinical skills.
Givati, Assaf, Harper, Mick, Markham, Chris   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Good Statistical Practice—development of tailored Good Clinical Practice training for statisticians

Trials
Background Statisticians are fundamental in ensuring clinical research, including clinical trials, are conducted with quality, transparency, reproducibility and integrity.
Deborah D. Stocken, Helen Mossop, Emma Armstrong, Steff Lewis, Susan J. Dutton, Claire Peckitt, Carrol Gamble, Julia Brown   +7 more
doaj   +1 more source