Results 91 to 100 of about 5,045,272 (312)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Healthcare Associated Infections. educational intervention by "Adult Learning" in an Italian teaching hospital [PDF]

, 2016
An educational intervention for HAI prevention based on a combination of training, motivation and subsequent application in the current clinical practice in an Italian teaching ...
Berdini, S, De Luca, A, DI NINNO, Filippo, Ferretti, Filippo, Marani, Alessandra, Montesano, M, Napoli, Christian, Orioli, Riccardo, Orsi, Giovanni Battista, Petruccioli, M. C, Rinaldi, Alessandro, Tarsitani, Gianfranco   +11 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Development and validation of a cardiometabolic multimorbidity prediction model in middle-aged and older adults

Scientific Reports
Cardiometabolic multimorbidity (CMM) is a prevalent syndrome among middle-aged and older adults, significantly impairing quality of life and imposing substantial health and economic burdens on China’s aging healthcare system.
Hongjiang Li, Xin Ma, Tingting Cui, Wenhui He, Liping Zhu, Hongling Zhang   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Chinese expert consensus statement on metformin in clinical practice

Chinese Medical Journal, 2020
Expert Group of Metformin in Clinical Practice, Li-Shao Guo   +1 more
doaj   +1 more source

Knowledge and attitude of human Mpox viral infection among pharmacy students in Jazan University: a web based cross-sectional study

Frontiers in Public Health
IntroductionSaudi Arabia has witnessed the first confirmed case of Mpox on July 14th, 2022. Currently, there is no approved medication for the treatment of this infection. Therefore, prevention of this infection is crucial.
Eman Merghani Ali, Eman Merghani Ali, Amani Khardali, Amani Khardali, Nawazish Alam, Nawazish Alam, Abdulkarim M. Meraya, Abdulkarim M. Meraya, Hilal A. Thaibah, Hilal A. Thaibah, Dalin A. Hassan, Mohamed Eltaib Elmobark, Alanood Aladwani, Alanood Aladwani, Anugeetha Thacheril Mohanan, Hanan A. Bakri, Zamzam O. Mashraqi, Areej Mousa Salhabi   +17 more
doaj   +1 more source

Supporting carers of people diagnosed with schizophrenia: evaluating change in nursing practice following training [PDF]

, 2003
<i>Background</i>: United Kingdom legislation and clinical standards for schizophrenia challenge nurses to re-examine the support that they provide to carers.
Abrouzzese, Atkin, Atkinson, Berg, Bernheim, Brooker, Brooker, Casey, Cervero, Chambers, CSBS, CSBS, Cuijpers, Dixon, DoH, DoH, Evandrou, Gall, Goodman, Gray, Hancock, Hatfield, Hatfield, Henwood, Hirst, James, Kellett, Magorrian, Mari, Milleken, Neary, Nolan, Nolan, Nolan, Nolan, Nolan, Nolan, Oldridge, Provencher, Repper, Rose, Scheller, Simpson, Spaniol, Szmukler, Tennakoon, Twigg, Waddell, Walker, Warner, Winefield, Wray   +51 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source