Results 91 to 100 of about 18,067,200 (315)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
POLYMORBIDITY IN CLINICAL PRACTICE
Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2014 На примере клинического случая рассматривается взаимовлияние заболеваний на их клиническую картину, характер течения, качество жизни пациентов и выбор лекарственной терапии. Изложены диагностика, постановка клинического диагноза и выбор оптимальной медикаментозной тактики у пациентки с полиморбидной патологией.
Uvarova, K. +7 more
openaire +2 more sources
Scientific ReportsCardiometabolic multimorbidity (CMM) is a prevalent syndrome among middle-aged and older adults, significantly impairing quality of life and imposing substantial health and economic burdens on China’s aging healthcare system.
Hongjiang Li +5 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Psychiatria Danubina, 2014 Much more is known about attitudes toward mental illness and social stigma, the viscious cycle of its consequences and how to fight the social stigma in public, but much less is known about how to combat the stigma and self stigma in clinical practice. Stigma theories have not been enough to understand the feelings and experience of people with mental ...
openaire +3 more sources
Chinese expert consensus statement on metformin in clinical practice
Chinese Medical Journal, 2020 Expert Group of Metformin in Clinical Practice +1 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Acute Medicine & Surgery, 2022 Guideline Committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020
doaj +1 more source