Results 141 to 150 of about 1,387,679 (310)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.

Kidney International
Paul E. Stevens, Sofia B. Ahmed, J. Carrero, Bethany J Foster, Anna Francis, Rasheeda K. Hall, Will G. Herrington, Guy Hill, Lesley A. Inker, R. Kazancioglu, Edmund Lamb, Peter Lin, Magdalena Madero, Natasha McIntyre, K. Morrow, Glenda Roberts, Dharshana Sabanayagam, E. Schaeffner, Michael G. Shlipak, Rukshana Shroff, Navdeep Tangri, T. Thanachayanont, I. Ulasi, Germaine Wong, Chih-Wei Yang, Luxia Zhang, Adeera Levin   +26 more
semanticscholar   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

2024 Japan Society for Stereotactic and Functional Neurosurgery Guidelines for Stereotactic and Functional Neurosurgery

Neurologia Medico-Chirurgica
Clinical Practice Guideline Committee of the Japan Society for Stereotactic and Functional Neurosurgery
doaj   +1 more source

Clinical Practice Guidelines Registry

Annals of Internal Medicine, 2021
Elaine Harrow, Sara Twaddle, Duncan Service, Ina B. Kopp, Pablo Alonso-Coello, Gillian Leng   +5 more
openaire   +3 more sources

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Introducing a Clinical Practice Guideline Using Early CT in the Diagnosis of Scaphoid and Other Fractures

Western Journal of Emergency Medicine, 2009
Objective: We developed and implemented clinical practice guideline (CPG) using computerized tomography (CT) as the initial imaging method in the emergency department management of scaphoid fractures.
Pincus, Steven, Weber, Merle, Meakin, Alex, Breadmore, Ross, Mitchell, David, Spencer, Luke   +5 more
doaj  

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.

Clinical Infectious Diseases, 2016
P. Pappas, C. Kauffman, D. Andes, C. Clancy, K. Marr, L. Ostrosky-Zeichner, A. Reboli, M. Schuster, J. Vázquez, T. Walsh, T. Zaoutis, J. Sobel   +11 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source