Results 31 to 40 of about 706,081 (215)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Critical ovarian hyperstimulation syndrome leading to severe malnutrition: shedding some lights on an extremely rare case report from Vietnam and narrative review

BMC Pregnancy and Childbirth
Background Ovarian hyperstimulation syndrome (OHSS) is a self-limited iatrogenic complication of controlled-ovarian stimulation. The condition occurs spontaneously or secondary to exogenous gonadotropins which may cause a severe condition.
Anh Dinh Bao Vuong, Ngoc Hai Tran, Tuan Kiet Tao, Phuc Nhon Nguyen   +3 more
doaj   +1 more source

Duration of late-follicular elevated progesterone and in vitro fertilization outcomes in pituitary down-regulation treatment cycles

Frontiers in Endocrinology, 2023
BackgroundThe objective of this study was to explore whether the duration of LFEP (late-follicular elevated progesterone) affected pregnancy outcomes in IVF (in vitro fertilization) patients treated with pituitary downregulation protocols.MethodPatients ...
Jiaxin Zhang, Xiaofei Ge, Zhiqin Bu
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

EUROPEAN TERATOLOGY INFORMATION SERVICE: EXPERIENCE, PROBLEMS AND PERSPECTIVES

Педиатрическая фармакология, 2007
Congenital malformations are still the important medical and social issue. They take the second place among the reasons for the infant mortality and cause up to 18,3% of disablement cases among the children. Exogenous factors, effecting the growing fetus,
A.V. Ostrovskaya, K. Schefer, L. von Stackelberg   +2 more
doaj   +2 more sources

Automated quantitative evaluation of fetal atrioventricular annular plane systolic excursion before and after intrauterine blood transfusion in pregnancies affected by red blood cell alloimmunization

Acta Obstetricia et Gynecologica Scandinavica
Introduction Maternal red blood cell alloimmunization during pregnancy can lead to hemolysis and various degrees of fetal anemia, which can be treated with intrauterine blood transfusion (IUT) to prevent adverse outcomes. Knowledge about fetal myocardial
Aikaterini Zamprakou, Ingrid Söderhult, Kjerstin Ferm‐Widlund, Gunilla Ajne, Jonas Johnson, Lotta Herling   +5 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Pregnancy outcome after first-trimester exposure to JAK inhibitors - an evaluation of the German Embryotox cohort

BMC Pharmacology and Toxicology
Background Janus kinase inhibitors (JAKi) are increasingly being used in the management of autoimmune diseases across rheumatology, gastroenterology, and dermatology, including in women of childbearing age. Consequently, pregnancies occurring during JAKi
Anna-Sophia Habbel, Evelin Beck, Anne Mueller, Katarina Dathe   +3 more
doaj   +1 more source