Results 101 to 110 of about 2,749,598 (311)

Experience with the use of Rituximab for the treatment of rheumatoid arthritis in a tertiary Hospital in Spain: RITAR study [PDF]

, 2019
There is evidence supporting that there are no relevant clinical differences between dosing rituximab 1000 mg or 2000 mg per cycle in rheumatoid arthritis (RA) patients in clinical trials, and low-dose cycles seem to have a better safety profile ...
Alvaro García, José M., Benedí, Juana, Castañeda, Santos, Cañamares, Iciar, García Vadillo, Alberto, González Álvaro, Isidoro, Llorente, Irene, López Bote, Juan Pedro, López, Jorge, Merino, Leticia, Muñoz Calleja, Cecilia, Ramírez, Esther   +11 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence. [PDF]

, 2014
The present paper summarizes the preclinical and clinical studies conducted to define the "anti-alcohol" pharmacological profile of the prototypic GABAB receptor agonist, baclofen, and its therapeutic potential for treatment of alcohol use disorder (AUD).
Agabio R, Colombo G
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

CLINICAL PROFILE OF PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA DUE TO 21 HYDROXYLASE DEFIICIENCY

National Journal of Medical Research, 2016
Introduction: 21 Hydroxylase deficiency is the most common enzymatic deficiency seen in XX-DSDs. 11-deoxycorticosterone and 11-deoxycortisol are deficient in the most-severe, “salt-wasting” form of this disease.
Sheeraz A Dar, Bashir A Charoo, Iqbal A Qzai, Javeed I Bhat, Mushtaq A Sheikh, Ikhlas Ahmad, Wajid Ali Syed, Asif Ahmed   +7 more
doaj  

First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI) [PDF]

, 2012
The objective of this pilot clinical study was to assess the safety, technical feasibility, pharmacokinetic (PK) profile and tumour response of DC Bead™ with irinotecan (DEBIRI™) delivered by intra-arterial embolisation for the treatment of metastatic ...
Eichler, Katrin, Gallus, Christof, Gruber-Rouh, Tatjana, Hammerstingl, Renate Maria, Mack, Martin G., Vogl, Thomas J., Zangos, Stephan   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Profile and associated factors of Syndrome-X at a tertiary hospital in Western Maharashtra [PDF]

Al Ameen Journal of Medical Sciences, 2014
Background: India is in the midst of epidemiological transition with increasing global burden of chronic non-communicable diseases accounting for 60% of the global deaths, 80% of which are in the developing World.
Shekhar S. Rajderkar, Veenit K. Phalake, Kriti A. Patel, Priya M. Prabhu, Jayashree D. Naik   +4 more
doaj  

SYSTEM AND METHOD FOR DETERMINING THE DEGREE OF ABNORMALITY OF A PATIENT'S VITAL SIGNS [PDF]

, 2006
A system and method for determining the degree of abnormality of a vital sign of a patient by obtaining the clinical profile of said patient and determining the statistical difference between the vital sign of the patient and the vital signs of ...
Kline, Jeffrey A.
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source