Results 61 to 70 of about 8,340,302 (256)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine [PDF]

, 2016
Purpose: To examine the pharmacokinetic (PK) profile of several candidate extended-release (ER) formulations of capecitabine in patients. Methods: In a phase 0 clinical study, PK profiles of several oral candidate ER formulations of capecitabine were ...
Schellens, Jan H M, Huitema, Alwin D R, Beijnen, Jos H., Pluim, Dick, Tibben, Matthijs M., de Vries, Niels, Jacobs, Bart A W, Marchetti, Serena, Meulenaar, Jelte, Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology, Rosing, Hilde, Nuijen, Bastiaan   +12 more
core   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

CLINICAL PROFILE OF SEGMENTAL VITILIGO IN A GROUP OF PAKISTANI PATIENTS

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine clinical profile of segmental vitiligo in a group of patients reporting to Combined Military Hospital Kohat. Study Design: A descriptive study.
Aamir Habib
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Diagnosis and staging of patients with ovarian cancer: National Clinical Guideline No. 20 Annex 1: Systematic review of cost effectiveness

, 2018
The purpose of this systematic review was to identify and evaluate economic evidence to inform the clinical recommendations of this NCG. Review of the cost-effectiveness of health technologies enables guideline developers to explicitly consider how ...
HRB-CICER (Collaboration in Ireland for Clinical Effectiveness Reviews)
core  

Clinical, cognitive, and sociodemographic variables in melancholic versus nonmelancholic depression

Social Health and Behavior, 2020
Introduction: The “biological” symptoms in some depressive illnesses are loss of sleep, appetite and weight, psychomotor changes, decreased libido, etc., Those in the remaining forms of depression include anxiety, phobias, and obsessional symptoms. These
Samin Sameed, Mathews Joseph Panicker, Rohan Dilip Mendonsa, Anil Kakunje, Ravichandra Karkal   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Aripiprazole: from pharmacological profile to clinical use

, 2015
Guido Di Sciascio,1 Marco Andrea Riva21Department of Psychiatry, University Hospital “Policlinico”, Bari, Italy; 2Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, ItalyAbstract: Clinical experience ...
Di Sciascio G, Riva MA
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source