Results 131 to 140 of about 1,276,580 (262)

Vertical Dimension in Prosthodontics Theory and Practice (Part III): Contemporary Clinical Protocols and Decision-Making for Loss of Vertical Dimension of Occlusion. [PDF]

Cureus
Fayad MI, Moussa R, Abdel-Gawwad EA, Laithy AA, Mahmoud EE, Shon AA, Hassan SM, Karam Eldain A, Alwakeel B, Helal MA.   +9 more
europepmc   +1 more source

Hearing aids to support cognitive functions of older adults at risk of dementia: the HearCog trial- clinical protocols. [PDF]

BMC Geriatr, 2020
Jayakody DMP, Almeida OP, Ford AH, Atlas MD, Lautenschlager NT, Friedland PL, Robinson S, Makate M, Coetzee L, Liew ASP, Flicker L.   +10 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identification of key upper-limb muscles during a standardized reach-to-grasp task toward simplified clinical protocols. [PDF]

Front Bioeng Biotechnol
Cabezaolias C, Garcia S, Sanchez C, Rodriguez R, Raya R, Urendes E.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Clinical Protocols for the Initial Evaluation and Follow-Up of Patients with Chronic Chagas Disease: A Proposal for Referral Centers. [PDF]

Trop Med Infect Dis
Hasslocher-Moreno AM, Rohem ACR, Costa ARD, Sousa AS, Mendes FSNS, Carneiro FM, Mazzoli-Rocha F, Silva GMSD, Veloso HH, Portela LF, Sangenis LHC, Holanda MT, da Silva PS, Saraiva RM, Xavier SS, Mediano MFF.   +15 more
europepmc   +1 more source

Cytokine Removal in Critically Ill Patients Requiring Surgical Therapy for Infective Endocarditis (RECReATE): An Investigator-initiated Prospective Randomized Controlled Clinical Trial Comparing Two Established Clinical Protocols. [PDF]

Medicine (Baltimore), 2020
Gisler F, Spinetti T, Erdoes G, Luedi MM, Pfortmueller CA, Messmer AS, Jenni H, Englberger L, Schefold JC.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A comprehensive investigation of the radiation isocentre spatial variability in linear accelerators: implications for commissioning, QA, and clinical protocols. [PDF]

Phys Eng Sci Med
Chen ZH, Riis HL, White R, Milan T, Rowshanfarzad P.   +4 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source