Results 51 to 60 of about 1,974,839 (304)

Optimisation of pharmacy content in clinical cancer research protocols: Experience of the United Kingdom Chemotherapy and Pharmacy Advisory Service [PDF]

, 2015
Background: Clarity and accuracy of the pharmacy aspects of cancer clinical trial protocols is essential. Inconsistencies and ambiguities in such protocols have the potential to delay research and jeopardise both patient safety and collection of credible
Daniels, Susanna, Debruyne, Philip R., Greer, Rachel, Harvey, Sally, Hodgkinson, Elizabeth, Johnson, Philip J., Kelly, Stephen, Kimber, Donna, Loucaides, Eileen, Lycke, Michelle, Mason, Julie, Parmar, Mahesh K.B., Pottel, Lies, Samol, Jens   +13 more
core   +1 more source

Comparison of two different protocols for the induction of maturation of human dendritic cells in vitro [PDF]

Vojnosanitetski Pregled, 2004
Background. Dendritic cells (DC) have been used for immunotherapy of malignant tumors, different kinds of infections, and other clinical conditions. For that purpose, optimal conditions for the generation of functionally mature DC in vitro are required ...
Čolić Miodrag J., Mojsilović Slavko, Pavlović Bojan, Vučićević Dragana, Majstorović Ivana, Bufan Biljana, Stojić-Vukanić Zorica, Vasilijić Saša, Vučević Dragana, Gašić Sonja, Balint Bela J.   +10 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Clinicopathological characteristics, diagnosis and treatment of melanoma in Serbia: The Melanoma Focus Study [PDF]

Vojnosanitetski Pregled, 2015
Background/Aim. Treatment options for metastatic melanoma in Serbia are limited due to the lack of newly approved biologic agents and the lack of clinical studies.
Kandolf-Sekulović Lidija, Babović Nada, Balić Mirjana, Nikolin Borislava, Nikolić Dejan, Janjić Zlata, Jokić Neven, Mijušković Željko, Rajović Milica, Novaković Marijan, Vrbić Svetislav, Pejčić Ivica, Kovačević Predrag, Mihajlović Dragan, Roganović Tatjana, Ferenc Vicko, Nikolić Jelena, Marinković Marija, Bizetić Zorana   +18 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Assessment of image quality and dose calculation accuracy on kV CBCT, MV CBCT, and MV CT images for urgent palliative radiotherapy treatments. [PDF]

, 2016
A clinical workflow was developed for urgent palliative radiotherapy treatments that integrates patient simulation, planning, quality assurance, and treatment in one 30-minute session.
Barani, Igor, Braunstein, Steve, Cremers, Florian, Fogh, Shannon E, Held, Mareike, Morin, Olivier, Nakamura, Jean, Perez-Andujar, Angelica, Pouliot, Jean, Sneed, Penny K   +9 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Failure to remove bluetongue serotype 8 virus (BTV-8) from in vitro produced and in vivo derived bovine embryos and subsequent transmission of BTV-8 to recipient cows after embryo transfer [PDF]

, 2019
The behavior of BTV-8 in cattle is different from most other serotypes not only with regards to clinical signs but certainly with respect to virus transmission (transplacental, contact). Therefore, the possibility of virus transmission by means of embryo
De Clercq, Kris, De Leeuw, Ilse, Haegeman, Andy, Nauwynck, Hans, Oliveira, Andre, Van Soom, Ann, Vandaele, Leen   +6 more
core   +1 more source

India Hypertension Control Initiative: Blood Pressure Control Using Drug and Dose-Specific Standard Treatment Protocol at Scale in Punjab and Maharashtra, India, 2022

Global Heart
Background: Hypertension treatment coverage is low in India. A stepwise simple treatment protocol is one of the strategies to improve hypertension treatment in primary care.
Prabhdeep Kaur, Manikandanesan Sakthivel, Vettrichelvan Venkatasamy, Padmaja Jogewar, Sandeep S. Gill, Abhishek Kunwar, Meenakshi Sharma, Anupam Khungar Pathni, Kiran Durgad, Swagata Kumar Sahoo, Amol Wankhede, Navneet Kumar, Vishwajit Bharadwaj, Bidisha Das, Tejpalsinh Chavan, Suhas Khedkar, Lalit Sarode, Sampada D. Bangar, Ashish Krishna, Roopa Shivashankar, Parasuraman Ganeshkumar, Pragati Pragya, Balram Bhargava   +22 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source