Results 111 to 120 of about 60,396,491 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Comparison of Neurocognitive Effects of Blonanserin, Olanzapine, Aripiprazole, and Risperidone in Drug-Naïve First-Episode Schizophrenia

Neuropsychiatric Disease and Treatment
WanHeng Hu,1– 4,* BingJie Huang,1– 4,* XiaoDong Guo,1– 4 XiaoLin Yin,1– 4 XiangHe Wang,1– 4 YunFei Ji,1– 4 Yue Zheng,1– 4 TianQi Gao,1– 4 Chuan Shi,1– 4 Xin Yu,1– 4 Chengcheng Pu1– 4 1Department of Psychiatry, Peking University Sixth ...
Hu W, Huang B, Guo X, Yin X, Wang X, Ji Y, Zheng Y, Gao T, Shi C, Yu X, Pu C   +10 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Study on the safety and efficacy of Fu's subcutaneous needling for the treatment of lumbar disc herniation: a systematic review and meta analysis of randomized controlled trials

Frontiers in Neurology
PurposeSystematic evaluation of the effectiveness and safety of Fu's Subcutaneous Needling (FSN) in the treatment of Lumbar Disc Herniation.MethodsA systematic search was conducted across four Chinese and four English databases, including China National ...
Jiao Liang, Jin Zhang, Jie Zhou, Kun Yang, Qian Xiong   +4 more
doaj   +1 more source

Clinical Psychology Today Vol 3 Issue 1 (Summer 2019)

, 2019
'Clinical Psychology Today' a journal for Clinical Psychologists to share research, practice and exchange views on the science and practice of Clinical Psychology.
Collins, Padraig, McHugh, Patrick, Melia, Ruth   +2 more
core  

General Summary and Abstracts: Department of Clinical Research [PDF]

, 1976
research ...
Department of Clinical Research, 49043
core  

Publishing the Findings of Clinical Research

, 1993
Current regulations and practice may not prevent a sponsor of clinical research from delaying or preventing the dissemination of findings that do not support his or her commercial, professional, or managerial interests.
Munro, A.J.
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The impact of Covid-19 on health research charities

, 2021
HRCI conducted a survey of its members in December 2020 to ascertain the impact of Covid-19 on Irish Health Research Charities.
Health Research Charities Ireland, /
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source