Results 101 to 110 of about 60,396,491 (305)

The role and challenges of clinical research coordinators: insights from a national survey

BMC Medical Research Methodology
Background Clinical research coordinators (CRCs) play a vital role in the management and execution of clinical trials, particularly in oncology and hematology.
Celeste Cagnazzo, Sara Testoni, Desirèe Speranza, Francesca Mannozzi, Stefano Stabile, Irene Federici, Marta Betti, Alessandra Ferrari, Linda Penolazzi, Veronica Franchina   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Clinical Psychology Today Vol 2 Issue 2 (Winter 2018)

, 2018
'Clinical Psychology Today' a journal for Clinical Psychologists to share research, practice and exchange views on the science and practice of Clinical Psychology.
Collins, Padraig, Moloney, Olive, Melia, Ruth   +2 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Estimating long COVID-19 prevalence across definitions and forms of sample selection

Frontiers in Epidemiology
IntroductionLong COVID (LC) is a multisystem condition with prolonged symptoms persisting beyond acute SARS-CoV-2 infection. However, prevalence estimates vary widely due to differences in case definitions and sampling methodologies.
Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Marta Colaneri, Alessandra Bandera, Alessandra Bandera, Andrea Gori, Andrea Gori, Amedeo Ferdinando Capetti   +10 more
doaj   +1 more source

Improving clinical research

BMJ, 2003
Failure to support clinical research now will cost human lives later In the post-genome era, clinical research couldn't be simpler. Exposure to human disease stimulates an enquiring mind to investigate underlying pathogenesis or new therapeutictargets. New functions are ascribed to genes that shed new light on cellular biology.
openaire   +3 more sources

The Essential Role of the Clinical Research Nurse (CRN)

, 2010
In an age of increasing focus on expanding the opportunity of clinical research trial participation to broader patient populations, the clinical research nurse (CRN) has become an essential member of the clinical research team. The CRN is responsible for
Buescher, Christine R., Poston, Rebecca Deal   +1 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience

Pharmaceuticals
Lysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects.
Hossein Omidian, Alborz Omidian
doaj   +1 more source

Human metapneumovirus infection among children in Taiwan: a comparison of clinical manifestations with other virus-associated respiratory tract infections

, 2008
[[abstract]]This study compared the clinical, laboratory and radiological features of infections caused by human metapneumovirus (hMPV) with other respiratory viruses.
Wang, SM; Liu, CC; Wang, HC; Su, IJ; Wang, JR
core   +1 more source