Results 81 to 90 of about 10,267,908 (249)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Research on work engagement of clinical psychologists [PDF]
, 2020 本研究は、これまで着目されてこなかった臨床心理士のワーク・エンゲイジメントの特徴と、個人の資源である自己効力感及びコーピング特性、家族の有無、仕事の資源である同業者からのサポートと職場満足感との関連について検討することを目的とした。137名の臨床心理士有資格者に質問紙調査を行った結果、ワーク・エンゲイジメントは一般勤労者や他の対人援助職者と比較して高い傾向が示された。また、ワーク・エンゲイジメントの高い者は、個人の資源としては自己効力感や積極的な問題解決コーピングが高く、子どもがいる者が多かった。さらに、
Kagawa Kaoru +3 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The Ethics of Using a Live Patient for Dental Board Exams [PDF]
, 2020 Objective: This study will discuss the various viewpoints regarding the ethics of using a live patient for board examination in dentistry. It will expand upon the inconsistency of the exam to include the compromised patient care, dishonorable delay in ...
Christ, Ashley, Gibbs, Aaliyah
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Clinical research practice [PDF]
, 1998 published_or_final_versio
Karlberg, JPE, Lui, WF, Tsang, K
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Clinical handover within the emergency care pathway and the potential risks of clinical handover failure (ECHO) : primary research [PDF]
, 2014 Background and objectives: Handover and communication failures are a recognised threat to patient safety. Handover in emergency care is a particularly vulnerable activity owing to the high-risk context and overcrowded conditions.
Chessum, Peter +8 more
core