Results 151 to 160 of about 60,673,388 (296)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Optimizing participant recruitment and retention in clinical studies by hearing the voices of persons with Parkinson's. [PDF]

J Parkinsons Dis
Goh XY, Shambetova C, Toh TS, Zhunusova E, Tay YW, Chua JP, Han WH, Lim JYL, Tan AH, Lim SY.   +9 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Of timescales, animal modeling and human diseases

Frontiers in Neurology, 2013
Denes V Agoston
doaj   +1 more source

Donidalorsen for the Treatment of Hereditary Angioedema: A Review of Clinical Studies. [PDF]

Drug Des Devel Ther
Riedl MA, Craig T, Lumry WR, Bordone L, Treadwell S, Yarlas A, Newman KB, Cohn DM.   +7 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Recent biological and pharmacological activities of naringenin in clinical studies. [PDF]

EXCLI J
Aljasmi F, Vazhappilly CG.
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A Comparative Analysis of the Quality of Root Canal Fillings of In Vivo Studies Conducted in Saudi Arabia and Worldwide: A Systematic Review

Clinical, Cosmetic and Investigational Dentistry
Abdulmajeed Saeed Alshahrani,1 Ahmed Ali Alelyani,1 Sadun Mohammad Al Ageel Albeaji,2 Dalia AlHarith,3 Ahmed Abdullah A Al Malwi,4 Abdulrahman Abdullah Aldhbaan,5 Khaled Saleh J Alshehri,6 Alwaleed Essam Bakri,7 Abdullah Ahmed Ali Sahli,8 Wafa Hassan ...
Alshahrani AS, Alelyani AA, Al Ageel Albeaji SM, AlHarith D, Al Malwi AAA, Aldhbaan AA, Alshehri KSJ, Bakri AE, Sahli AAA, Alaajam WH, Al Moaleem MM   +10 more
doaj