Results 171 to 180 of about 6,034,431 (246)

Biomaterials for vertebral body repair: interior augmentation and total replacement-a literature review of bone fusion outcomes in clinical studies. [PDF]

J Spine Surg
Moura DL, Casal D, Lourenço P, Jardim C, Fonseca F, Casanova J, Bernardes A.   +6 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Variational biomarker pooling with calibration for time-to-event outcomes across multiple clinical studies. [PDF]

BMC Med Res Methodol
Song J, Rong Z, Hou Y.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanical and Biological Treatments for Annulus Fibrosus Repair and Closure: A Review of Clinical Studies. [PDF]

Neurospine
Willett N, Ikwuegbuenyi CA, Wang E, Chung LK, Robayo A, Antar A, Elsayed G, Vadalà G, Hussain I, Härtl R, AO Spine Knowledge Forum Degenerative.   +10 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Potential of Authorised Drugs to be Repurposed for the Treatment of Osteoarthritis: A Scoping Review of Clinical Studies. [PDF]

Drugs
Heijman MWJ, Hartog M, van den Ende CHM, Popa CD, van den Bemt BJF.   +4 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Clinical Studies on Topical Anesthesia in Dentistry: A Bibliometric Analysis. [PDF]

Pharmaceuticals (Basel)
Dos Santos HCG, de Sousa ITC, Pestana AM, Bezerra AAC, Lucas ALM, Martins-Júnior PA, Franz-Montan M.   +6 more
europepmc   +1 more source