Results 241 to 250 of about 60,673,388 (296)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The effects of intravenous immunoglobulin on intestinal inflammation: a systematic review of animal and clinical studies. [PDF]

PeerJ
Chu T, Yuan X, Wang T, Zhang W, Yan X, Li C, Jiang P, Ye S, Ma L, Sun P, Du X, Fu P, Wang Z.   +12 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Editorial: Dysfunctional motivation in eating behaviors: a complex gene x environment interplay

Frontiers in Behavioral Neuroscience
Kirrilly Pursey, Kirrilly Pursey, Lucy Babicola, Lucy Babicola, Rossella Ventura, Rossella Ventura, Matteo Di Segni, Matteo Di Segni   +7 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A 25-year landscape of Escherichia coli vaccine development: systematic review of human clinical studies. [PDF]

NPJ Vaccines
Rostamian M, Shahbazi S, Lorestani RC, Zargaran FN, Bahrami Y.   +4 more
europepmc   +1 more source

Prophylactic Regenerative Peripheral Nerve Interfaces for Prevention of Postamputation Pain: A Systematic Review and Meta-Analysis of Comparative Clinical Studies. [PDF]

J Clin Med
Gabriyanchik M, Pirogov K, Startseva O, Meskhi K, Reshetov I.   +4 more
europepmc   +1 more source

Cardioprotective potential of Maharishi Amrit Kalash: a scoping review of evidence from experimental and clinical studies. [PDF]

Front Pharmacol
Singh R, Vohra R, Shrivastava R, Schneider RH.   +3 more
europepmc   +1 more source

Science policies and practice of including and excluding women from clinical studies: focus on cardiovascular research. [PDF]

Front Physiol
Kovalsky A, Levitan I.
europepmc   +1 more source