Results 111 to 120 of about 8,585,360 (297)

Pharmacogenetics in Tuberculosis-HIV Coinfected Populations: A Systematic Review of Genetic Variants Influencing Antiretroviral and Anti-Tuberculosis Drug Response

Journal of Multidisciplinary Healthcare
Harri Hardi,1 Zahra Fitrianti,1 Liganda Endo Mahata,1,2 Melva Louisa3 1Clinical Pharmacology Specialist Study Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Pharmacology and Therapy, Faculty of Medicine ...
Hardi H, Fitrianti Z, Mahata LE, Louisa M   +3 more
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy

Frontiers in Medicine
ObjectiveA new Tripterygium wilfordii preparation called Kunxian capsule (KX) has been approved in China. However, it is still unknown whether KX is safe and effective for idiopathic membranous nephropathy (IMN) and its therapeutic mechanism of action is
Jia Lv, Xinyu Gao, Lihua Liu, Libing He, Geng Tian, Xuehong Lu   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Activity of recombinant human interleukin-21 (rIL-21) in patients (pts) with stage IV malignant melanoma (MM) without prior treatment : clinical data from a phase IIa study

, 2008
Background: IL-21 has a key role in cancer immunology. We have previously described a phase 1 study of rIL-21 in pts with advanced MM. We now report final clinical results from a phase 2a study in treatment-naïve pts with advanced MM. Methods: Open-label,
Davis, I. D, Kefford, R, Kristjansen, P. E, Millward, M. J, McArthur, G. A, Skrumsager, B. K, Mouritzen, U, Brady, B   +7 more
core  

Intracoronary Gene Delivery of the Cytoprotective Factor Vascular Endothelial Growth Factor-B167 in Canine Patients with Dilated Cardiomyopathy: A Short-Term Feasibility Study

Veterinary Sciences, 2019
Dilated cardiomyopathy (DCM) is a myocardial disease of dogs and humans characterized by progressive ventricular dilation and depressed contractility and it is a frequent cause of heart failure.
Paola Paradies, Lucia Carlucci, Felix Woitek, Francesco Staffieri, Luca Lacitignola, Luigi Ceci, Daniela Romano, Mariateresa Sasanelli, Lorena Zentilin, Mauro Giacca, Stefano Salvadori, Antonio Crovace, Fabio A. Recchia   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Relapse rate after adjuvant trastuzumab in the northeast of Italy: Preliminary data from a multicenter observational study in a clinical setting. J Clin Oncol 30, 2012 (suppl; abstr 586)

, 2012
Background: Relapse Rate (RR) after Adjuvant Trastuzumab (AT) reported in clinical trials is between 15 and 21%. Information on RR and clinical behaviour of HER2-POS metastatic disease after AT outside clinical trials is limited.
AM Molino, on Behalf of Italian North East HER2 STUDY GROUP, MUSTACCHI, GIORGIO, E. Fiorio   +3 more
core  

Status of periodontal health in German patients suffering from chronic kidney disease - data from the GCKD study

, 2019
Aim: To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self‐reported periodontitis awareness of the study subjects.
Wanner, Christoph, Barthlein, B., Christoph Wanner, Kai‐Uwe Eckardt, Sommerer, C., Dannewitz, Bettina, Ulrich Schlagenhauf, Vera Krane, Wanner, C., Bärthlein, Barbara, Nadal, J., Claudia Sommerer, Jockel-Schneider, Y., Sommerer, Claudia, Krane, Vera, Krane, V., Stölzel, Peggy, Jennifer Nadal, Nadal, Jennifer, Eckardt, Kai‐Uwe, Baid‐Agrawal, Seema, Eckardt, K. U., Jockel‐Schneider, Yvonne, Peggy Stölzel, Stolzel, P., Baid-Agrawal, Seema,, Dannewitz, B., Zeier, M., Zeier, Martin, Yvonne Jockel‐Schneider, Bettina Dannewitz, Schlagenhauf, Ulrich, Seema Baid‐Agrawal, Schlagenhauf, U., Martin Zeier, Barbara Bärthlein   +35 more
core   +1 more source

Bovine pericardium based non-cross linked collagen matrix for successful root coverage, a clinical study in human [PDF]

, 2012
Introduction: The aim of this study was to clinically assess the capacity of a novel bovine pericardium based, non-cross linked collagen matrix in root coverage. Methods: 62 gingival recessions of Miller class I or II were treated.
Sculean Anton, Sader Robert A, Willershausen Ines, Shahram Ghanaati, Ines Willershausen, Ghanaati, Shahram Michael, Anton Sculean, Ghanaati Shahram, Robert A. Sader, Sader, Robert A, Schlee, Markus, Sader, Robert Alexander, Stimmlmayr Michael, Schlee Markus, Markus Schlee, Sculean, Anton, Ghanaati, Shahram, Willershausen, Ines, Willershausen, Ines Bettina Anne, Stimmlmayr, Michael, Michael Stimmlmayr   +20 more
core   +1 more source