Results 101 to 110 of about 8,585,360 (297)

Clinical pharmacology of novel anticancer agents: bioanalysis - clinical pharmacokinetics - mass balance studies

, 2016
Cancer is already among the leading causes of death worldwide and the number of new cases is expected to rise by about 70% over the next two decades. Even though the number of new cases will rise, the survival rates are also increasing due to earlier ...
Pharmacoepidemiology and Clinical Pharmacology, Nijenhuis, Cynthia M   +1 more
core  

OCRIPLASMIN FOR VITREOMACULAR TRACTION IN CLINICAL PRACTICE: The INJECT Study.

, 2021
Randomized clinical trials have demonstrated the safety and efficacy of ocriplasmin in patients with vitreomacular traction (VMT), including those with macular hole (MH).
Stappler, T., Steel, DHW, Karia, N., Wachtlin, J., Patel, N., Raber, T., Patton, N., Hoerauf, H., Kozma-Wiebe, P.   +8 more
core   +1 more source

A clinical case of diffuse odontogenic facial phlegmon

Patologìâ
The aim of the work is to describe and discuss an unusual clinical case of diffuse facial phlegmon in order to increase the awareness and competence of clinicians who may encounter similar cases. Materials and methods.
A. S. Varzhapetian, O. O. Kokar
doaj   +1 more source

脑血管病临床医师科研能力的培养 Cultivation of Scientific Research Ability of Cerebrovascular Disease Clinicians

Zhongguo cuzhong zazhi, 2019
临床研究是现代循证医学的基础，临床医师是临床研究的主要参与者，因此临床医师科 研素养和能力的培养对于临床试验的规范和医学科研的进步意义重大。本文主要探讨了临床研究医 师培养的必要性，明确临床研究能力的培养目标，积极探索临床研究能力的培养途径。通过培养医 师临床研究能力推动脑血管病事业持续发展。 Abstract: Clinical studies are the base of modern evidence-based medicine (EBM), and clinicians are ...
叶玉梅，陈瑛，许蓉，任依
doaj   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

A comparative case study of two models of a clinical informaticist service

, 2002
Objectives: To describe and evaluate two different models of a clinical informaticist service. Design A case study approach, using various qualitative methods to illuminate the complexity of the project groups' experiences. Setting UK primary health care.
Humphrey, C, Greenhalgh, T, Swinglehurst, D, Rogers, S, Greenhalgh, Trisha, Martin, P, Hughes, J   +6 more
core   +1 more source

Halitosis and Quality of Life in Young Orthodontic Patients: A Cross-Sectional Assessment of Mouthwash Use and Traditional, Rotative, and Sonic Toothbrushes

Medicina
Background and Objectives: Halitosis is common among orthodontic patients, potentially exacerbated by plaque retention around brackets. It was hypothesized that patients using sonic toothbrushes would report lower halitosis impact scores compared to ...
Hamsah Musa, Ioana Georgiana Pașca, Malina Popa, Octavia Bălean, Ramona Dumitrescu, Ruxadra Sava Roșianu, Atena Gălușcan, Roxana Oancea   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Clinical signs that predict severe illness in children under age 2 months: a multicentre study.

, 2008
BACKGROUND: Neonatal illness, particularly in the first week of life, is a leading cause of death worldwide. Improving identification of young infants who require referral for severe illness is of major public-health importance.
Young Infants Clinical Signs Study Group
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source