Results 101 to 110 of about 1,136,022 (274)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Frontiers in SurgeryBackground & aimsDeep vein thrombosis, a common complication after laparoscopic surgery, can negatively affect patients' limb motor function and even seriously threaten their lives.
Su-Zhen Yang +5 more
doaj +1 more source
The Strategic Impact of Clinical Practice Guidelines in Nursing on the Managerial Function of Supervision [PDF]
, 2013 José Antonio Romero +1 more
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
«The good learning situation» student perspective on learning in clinical placement
Fysioterapeuten, 2012 Introduction: Learning in clinical placement is a core element in development of competent and independent physiotherapists. Knowledge about learning processes in clinical placement is important to universities and workplaces in organizing of clinical ...
Anne Kari Skøien, Unni Vågstøl
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
PENINGKATAN KOMPETENSI GURU PADA PELAKSANAAN PEMBELAJARAN MELALUI SUPERVISI KLINIS DI SD BUNGKUS
Ideguru, 2018 This School Action Research conducted at SD Bungkus. The aims of this study were to 1). Improve the teacher competence especially in learning process through clinical supervision. 2). Know the appropriate steps of clinical supervision in order to improve
Suciati Suciati
doaj
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source