Results 101 to 110 of about 1,276,899 (300)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Shaping supervision practice through research: Effects of supervision for counselling practice

open access: yes, 2007
That there are links between effective supervision and effective counselling practice tends to be taken for granted. As a contribution to documenting the professional knowledges and experiences that might stand behind the profession’s claims for the ...
Rodwell, Jan   +11 more
core  

Recent bereavement, coping strategies, and symptoms of anxiety and insomnia in clinical psychology trainees

open access: yesFrontiers in Education
IntroductionClinical psychology trainees engaged in supervised training may be exposed to significant life stressors, such as bereavement, which can increase vulnerability to anxiety and insomnia symptoms.
Byron Fernando Bustamante-Granda   +3 more
doaj   +1 more source

Clinical Supervision Among Family Physicians

open access: yesJournal of Primary Care & Community Health, 2013
Background: Clinical supervision (CS) is not an established support system among physicians. Family physicians (FPs) have used Balint groups as a form of clinical supervision. In all, not much is known about the prevalence of physicians’ attendance to or
Martina A. Torppa   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

How do new practitioners come to understand and effectively use supervision?

open access: yes, 2010
This project investigated how new practitioners come to understand and effectively use supervision. It was based on a collaborative inquiry with supervisors and new practitioners who had met for supervision, and who volunteered to reflect on their ...
Wolfe, Rachel
core  

Nursing tutors' perception of clinical supervision skills [PDF]

open access: yes, 2016
Introduction: The evolution of science and technology, changes within the healthcare organizations and new healthcare emerging philosophies require an active participation from healthcare professionals in helping in their peers’ training. The supervision
Silva, Ernestina   +4 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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