Results 101 to 110 of about 6,934,145 (250)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Shaping supervision practice through research: Effects of supervision for counselling practice [PDF]

, 2007
That there are links between effective supervision and effective counselling practice tends to be taken for granted. As a contribution to documenting the professional knowledges and experiences that might stand behind the profession’s claims for the ...
Rodwell, Jan, Riches, Val, Flintoff, Vivianne, Rewita, Titihuia, Overdyck, Helga, McLachlan, Debbie, Crocket, Kathie, Gaddis, Stephen, Schoffelmeer, Ellie, Day, Caroline, Malcolm, Pam, Lammers, Marianne   +11 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

What Aspects of Supervised Patient Encounters Affect Students’ Perception of Having an Excellent Learning Outcome? A Survey Among European Medical Students

Advances in Medical Education and Practice, 2023
Cathinka Thyness,1 Aslak Steinsbekk,1 Vebjørn Andersson,2 Hilde Grimstad1 1Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 2Department of Neurology, Oslo University Hospital, Oslo ...
Thyness C, Steinsbekk A, Andersson V, Grimstad H   +3 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

‘I Feel Disempowered Because I Could Not Do Anything’: Clinical Facilitators' Perception of Violence Towards Nursing Students During Clinical Placement

Nursing Open
Aims To explore clinical facilitators' understanding, experiences and perceptions of their role in supporting registered nurse students (RNS) who experience workplace violence (WPV) during clinical placement.
Hila Ariela Dafny, Paul Cooper, Nasreena Waheed, Stephanie Champion, Christine Mccloud, Nicole Snaith, Leeanne Pront   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

How do new practitioners come to understand and effectively use supervision? [PDF]

, 2010
This project investigated how new practitioners come to understand and effectively use supervision. It was based on a collaborative inquiry with supervisors and new practitioners who had met for supervision, and who volunteered to reflect on their ...
Wolfe, Rachel
core  

The effect of Peer instructor teaching and clinical supervision on the status and stressors of clinical nursing education

Journal of Medical Education and Development, 2020
Introduction: Peer instructor teaching is an educational model in which senior students teach to their classmates or junior students. Clinical supervision is a formal, systematic, and continuous that the inexperienced person reviews and improves their ...
khadijeh nasiriani, mohammad zare reshkoeyeh, matin arman, samaneh mirzaei   +3 more
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source