Results 31 to 40 of about 6,934,145 (250)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Guidelines for enhancing clinical supervision

open access: yesHealth SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2003
Clinical supervision is widely recognised as important and constructive in nursing and other health professions, but how is it actually done? Opsomming Kliniese toesighouding word as belangrik en konstruktief beskou in verpleging en ander ...
Marthie C Bezuidenhout
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Exploring Group Clinical Supervision: Enhancing Professional Awareness and Unity in a Single-Group Case Study

open access: yesMediterranean Journal of Clinical Psychology
Background: Clinical supervision serves as a collaborative reflection mechanism, enabling clinicians to enhance their cognitive and emotional awareness of their practice.
Denise Vagnini   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Clinical Supervision: Technocratic Mindedness, or Emancipatory Learning

open access: yes, 1986
The author reflects on the disadvantages and potential of clinical educational supervision. He attributes the flaw of traditional forms of supervision to their conceptualization as a delivery of service to those who need it.
Smyth, John
core   +3 more sources

Engaging with clinical supervision in a community midwifery setting: an action research study [PDF]

open access: yes
The main aim of this research study was to explore midwives’ views and experiences of their support needs in clinical practice and then to identify how they would wish to receive such support. There was much literature to support the existence of stress
Deery, Ruth
core   +4 more sources

Nursing theories 2: Clinical supervision

open access: yes, 2017
Definition of clinical supervision Benefits of clinical supervision for patients and ...
Chapman, Hazel M.
core   +2 more sources

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