Results 41 to 50 of about 1,276,899 (300)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Becoming clinical supervisors: identity learnings from a registrar faculty development program

Perspectives on Medical Education, 2020
This article shares our experiences and surprises as we developed, implemented and evaluated a 12-week faculty development program for registrars as clinical supervisors over three cohorts.
Christy Noble, Jessica Young, Ellen Hourn, Dale Sheehan   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

District Health Managers' Perceptions of Supervision in Malawi and Tanzania. [PDF]

, 2013
Mid-level cadres are being used to address human resource shortages in many African contexts, but insufficient and ineffective human resource management is compromising their performance. Supervision plays a key role in performance and motivation, but is
Honorati Masanja, McAuliffe, Eilish, Camille Boostrom, Rachel Waxman, Francis Kamwendo, Waxman, Rachel, Kamwendo, F., Boostrom, Camille, Masanja, Honorati, Masanja, H., Boostrom, C., Bradley, Susan, de Pinho, H., Susan Bradley, Bradley, S., Waxman, R., Helen de Pinho, Kamwendo, Francis, de Pinho, Helen, McAuliffe, E., Eilish McAuliffe   +20 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exploring Group Clinical Supervision: Enhancing Professional Awareness and Unity in a Single-Group Case Study

Mediterranean Journal of Clinical Psychology
Background: Clinical supervision serves as a collaborative reflection mechanism, enabling clinicians to enhance their cognitive and emotional awareness of their practice.
Denise Vagnini, Chiara Fusar Poli, Antonia Sorge, Sara Molgora, Giuseppe Tarantino, Emanuela Saita, Barbara Bertani   +6 more
doaj   +1 more source

Clinical supervision in South Africa: Perceptions of supervision training, practices, and professional competencies

South African Journal of Science, 2021
We investigated South African clinical and counselling psychology supervisors’ (n=44) perceptions of supervision training, their supervision experiences, and their perceived competence, confidence and effectiveness in providing supervision.
Shariefa Hendricks, Duncan J. Cartwright, Richard G. Cowden   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The supervision needs of senior clinical psychologists [PDF]

, 2021
Section A This review critically evaluates the published literature regarding what sustains clinical psychologists in their careers over time. A systematic literature search of three online databases (PsychInfo, Assia and Web of Science) and a manual ...
Deegan, C.
core