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Frontiers in Bioscience, 2006
A clinical trial is a research study in human patients aimed at answering specific health questions. If a clinical trial is well-conducted, it is the fastest way to find treatments that work in people and ways to improve health. A clinical trial is one of the final stages of a long research process.
GIACINTI L., LOPEZ M., GIORDANO A.
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A clinical trial is a research study in human patients aimed at answering specific health questions. If a clinical trial is well-conducted, it is the fastest way to find treatments that work in people and ways to improve health. A clinical trial is one of the final stages of a long research process.
GIACINTI L., LOPEZ M., GIORDANO A.
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Archives of Neurology, 1989
Controlled clinical trials are becoming increasingly frequent in neurology. A review of the literature indicates that several trials have serious flaws in study design and conduct that render the results questionable or uninterpretable. These reports, together with my own experience with the trial of plasmapheresis in the treatment of acute Guillain ...
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Controlled clinical trials are becoming increasingly frequent in neurology. A review of the literature indicates that several trials have serious flaws in study design and conduct that render the results questionable or uninterpretable. These reports, together with my own experience with the trial of plasmapheresis in the treatment of acute Guillain ...
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Seminars in Surgical Oncology, 1996
The randomized clinical trial is a scientific method for solving clinical problems. The method is typically employed before a new type of treatment is offered on a major scale in order to safeguard patients against a less curative therapy. Especially with regard to cancer treatment, randomized studies are conducted in increasing numbers. However, there
M, Blichert-Toft +2 more
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The randomized clinical trial is a scientific method for solving clinical problems. The method is typically employed before a new type of treatment is offered on a major scale in order to safeguard patients against a less curative therapy. Especially with regard to cancer treatment, randomized studies are conducted in increasing numbers. However, there
M, Blichert-Toft +2 more
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Nursing Management, 2005
Are you involved in inviting patients to join clinical trials? The National electronic Library for Health (NeLH) has developed a website for people who are asked to take part, writes Ruth Williams.
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Are you involved in inviting patients to join clinical trials? The National electronic Library for Health (NeLH) has developed a website for people who are asked to take part, writes Ruth Williams.
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2003
The transition from laboratory testing to evaluation in humans marks an important stage in vaccine development. Questions about safety and benefit to the patient and to the community may raise difficult ethical issues, whereas the inherent variability of human responses must be taken into account to obtain valid estimates of vaccine effect. This latter
Paddy, Farrington, Elizabeth, Miller
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The transition from laboratory testing to evaluation in humans marks an important stage in vaccine development. Questions about safety and benefit to the patient and to the community may raise difficult ethical issues, whereas the inherent variability of human responses must be taken into account to obtain valid estimates of vaccine effect. This latter
Paddy, Farrington, Elizabeth, Miller
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Neurologic Clinics, 1990
Broad guidelines for the design, implementation, analysis, and reporting of results of clinical trials are given. The use of randomization, concurrent controls, and blinding is justified. Basic principles of the design of clinical trials are outlined and include the areas of specification of the hypothesis, definition of the outcome and the logistics ...
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Broad guidelines for the design, implementation, analysis, and reporting of results of clinical trials are given. The use of randomization, concurrent controls, and blinding is justified. Basic principles of the design of clinical trials are outlined and include the areas of specification of the hypothesis, definition of the outcome and the logistics ...
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The Milbank Memorial Fund Quarterly. Health and Society, 1981
This paper argues that scientific clinical trials are the most ethical way to benefit patients whenever there is uncertainty about proper diagnosis and therapy. An increasing number of trials reported in clinical journals have employed randomization since the 1st extensive use of randomized controlled trials after the 2nd World War.
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This paper argues that scientific clinical trials are the most ethical way to benefit patients whenever there is uncertainty about proper diagnosis and therapy. An increasing number of trials reported in clinical journals have employed randomization since the 1st extensive use of randomized controlled trials after the 2nd World War.
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Randomisation in clinical trials
Medical Journal of Australia, 2002Randomisation is the process of assigning clinical trial participants to treatment groups. Randomisation gives each participant a known (usually equal) chance of being assigned to any of the groups. Successful randomisation requires that group assignment cannot be predicted in advance.
Beller, E. M., Gebski, V .J., Keech, A.
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World Journal of Surgery, 1999
Abstract.The randomized clinical trial (RCT) is often referred to as the gold standard for the assessment of treatment efficacy. RCTs are receiving greater attention in the literature and higher priority by funding agencies than they have in the past.
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Abstract.The randomized clinical trial (RCT) is often referred to as the gold standard for the assessment of treatment efficacy. RCTs are receiving greater attention in the literature and higher priority by funding agencies than they have in the past.
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Journal of the American Statistical Association, 2001
Abstract One of the main driving forces behind the development of new statistical methods in recent years has been the importance of clinical trials both in public health initiatives and in industry. Public control of the release of new medications by national agencies has led to their more rigorous testing, with the accompanying need ...
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Abstract One of the main driving forces behind the development of new statistical methods in recent years has been the importance of clinical trials both in public health initiatives and in industry. Public control of the release of new medications by national agencies has led to their more rigorous testing, with the accompanying need ...
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