Results 101 to 110 of about 14,066,519 (402)

The Association Between Malaria Parasite Geometrical Mean and Clinical Spectrum of Severe Disease in a High-Transmission Setting in Eastern Uganda: A Cross-Sectional Study

Journal of Parasitology Research
Conclusion: In malaria high-transmission settings of Eastern Uganda, patients with severe malaria had low parasite GMs similar to those in uncomplicated malaria.
Emma Isaiah Eregu Egiru, Cate Namayanja, George Paasi, William Okiror, Paul Ongodia, Charles Benard Okalebo, Rita Muhindo, Grace Abongo, Faith Oguttu, Ambrose Okibure, Francis Okello, Crispus Tegu, David Mukunya, Martin Chebet, Peter Olupot-Olupot   +14 more
doaj   +1 more source

A simulation study comparing the power of nine tests of the treatment effect in randomized controlled trials with a time-to-event outcome

Trials, 2020
Background The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption
Patrick Royston, Mahesh K. B. Parmar
doaj   +1 more source

Clinical trial metadata:Defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme [PDF]

, 2015
Background:  By 2011, the Health Technology Assessment (HTA) programme had published the results of over 100 trials with another 220 in progress. The aim of the project was to develop and pilot ‘metadata’ on clinical trials funded by the HTA programme.  
Cook, Andrew, Davidson, Peter, Milne, Ruairidh, Raftery, James, Stanton, Louise, Turner, David, Young, Amanda   +6 more
core   +2 more sources

Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency.

American Journal of Kidney Diseases, 2019
The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) are currently willing to consider a 30% to 40% glomerular filtration rate (GFR) decline as a surrogate end point for kidney failure for clinical trials of kidney disease ...
A. Levey, R. Gansevoort, J. Coresh, L. Inker, H. Heerspink, Morgan E. Grams, T. Greene, H. Tighiouart, K. Matsushita, S. Ballew, Y. Sang, E. Vonesh, Jian Ying, Tom Manley, D. de Zeeuw, K. Eckardt, A. Levin, V. Perkovic, Luxia Zhang, K. Willis   +19 more
semanticscholar   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Cluster randomised controlled feasibility study of HENRY: a community-based intervention aimed at reducing obesity rates in preschool children

Pilot and Feasibility Studies, 2018
Background In the UK and beyond, public funding is used to commission interventions delivered in public health early years settings aimed at improving health and well-being and reducing inequalities in order to promote school readiness.
Maria Bryant, Wendy Burton, Michelle Collinson, Suzanne Hartley, Sandy Tubeuf, Kim Roberts, Annemijn E. C. Sondaal, Amanda J. Farrin   +7 more
doaj   +1 more source

Video assisted thoracic surgery for treatment of pneumothorax and lung resections: systematic review of randomised clinical trials [PDF]

, 2004
<b>Objectives</b> To determine if video assisted thoracic surgery is associated with better clinical outcomes than thoracotomy for three common procedures: surgery for pneumothorax, minor resections, and lobectomy.
Lewsey, J., Sedrakyan, A., Treasure, T., van der Meulen, J.   +3 more
core   +3 more sources

The SOFA score—development, utility and challenges of accurate assessment in clinical trials

Critical Care, 2019
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare settings and environments.In
S. Lambden, P. Laterre, M. Levy, B. François   +3 more
semanticscholar   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Incentives for Clinical Trials [PDF]

Who gains from more information on the quality of pharmaceutical drugs? Are there incentives for voluntary post-approval clinical trials among pharmaceutical companies?
Grönqvist, Erik, Lundin, Douglas
core