Results 131 to 140 of about 14,066,519 (402)

Practical methods for incorporating summary time-to-event data into meta-analysis: updated guidance

Systematic Reviews
Our previous guide to estimating hazard ratios (HRs) from published summary (aggregate) data has become very widely used, but many still have difficulties knowing when and how to apply the methods.
Jayne F. Tierney, Sarah Burdett, David J. Fisher   +2 more
doaj   +1 more source

Trends in mesenchymal stem cell clinical trials 2004‐2018: Is efficacy optimal in a narrow dose range?

Stem Cells Translational Medicine, 2019
The number of clinical trials using mesenchymal stem cells (MSCs) has increased since 2008, but this trend slowed in the past several years and dropped precipitously in 2018.
Maciej Kabat, Ivan Bobkov, Suneel Kumar, M. Grumet   +3 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Three-outcome designs for external pilot trials with progression criteria

BMC Medical Research Methodology
Background Whether or not to progress from a pilot study to a definitive trial is often guided by pre-specified quantitative progression criteria with three possible outcomes.
Duncan T. Wilson, Eleanor Hudson, Sarah Brown   +2 more
doaj   +1 more source

Validation of Time in Range as an Outcome Measure for Diabetes Clinical Trials

Diabetes Care, 2018
OBJECTIVE This study evaluated the association of time in range (TIR) of 70–180 mg/dL (3.9–10 mmol/L) with the development or progression of retinopathy and development of microalbuminuria using the Diabetes Control and Complications Trial (DCCT) data ...
R. Beck, R. Bergenstal, Tonya D. Riddlesworth, C. Kollman, Zhaomian Li, Adam S. Brown, Kelly L Close   +6 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Theoretically-informed vs standard cover letter to improve participant response to mailed questionnaire: results of an embedded randomised retention trial

Trials
Background Participant non-response is a source of bias in all research, especially in randomised controlled trials. Participants followed up remotely can have high non-response rates.
Colin C. Everett, Sarah T. Brown, Joanna L. Dennett, Howard Collier, Claire L. Davies, Frances Game, E Andrea Nelson   +6 more
doaj   +1 more source

Adult patients with supratentorial pilocytic astrocytoma: long-term follow-up of prospective multicenter clinical trial NCCTG-867251 (Alliance) [PDF]

, 2015
Paul D. Brown, S. Keith Anderson, Xiomara W. Carrero, Brian Patrick O’Neill, Caterina Giannini, E. Galanis, Sunjay Shah, Ross A. Abrams, Walter J. Curran, Jan C. Buckner, Edward G. Shaw   +10 more
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source