Results 221 to 230 of about 2,053,087 (266)
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World Journal of Surgery, 1999
Abstract.The randomized clinical trial (RCT) is often referred to as the gold standard for the assessment of treatment efficacy. RCTs are receiving greater attention in the literature and higher priority by funding agencies than they have in the past.
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Abstract.The randomized clinical trial (RCT) is often referred to as the gold standard for the assessment of treatment efficacy. RCTs are receiving greater attention in the literature and higher priority by funding agencies than they have in the past.
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Journal of the American Statistical Association, 2001
Abstract One of the main driving forces behind the development of new statistical methods in recent years has been the importance of clinical trials both in public health initiatives and in industry. Public control of the release of new medications by national agencies has led to their more rigorous testing, with the accompanying need ...
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Abstract One of the main driving forces behind the development of new statistical methods in recent years has been the importance of clinical trials both in public health initiatives and in industry. Public control of the release of new medications by national agencies has led to their more rigorous testing, with the accompanying need ...
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Immunotherapy: clinical trials – optimal trial and clinical outcomes
Current Opinion in Allergy and Clinical Immunology, 2007The methodology of randomized clinical trials is essential to assess and register treatment interventions. Although specific immunotherapy was introduced a century ago, very few trials meet the criteria for pivotal studies. The paper reviews the methods which should be used to investigate specific immunotherapy.Large pivotal trials on specific ...
Bousquet PJ +4 more
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Veterinary clinical trials are on trial
Veterinary Record, 2017Veterinary surgeons, nurses, and owners and farmers make clinical decisions every day that affect the health and welfare of the animals they care for. A large number of these decisions are focused on medical or surgical treatments. A recent study by Robinson and others (2017) found that for small animal consultations, therapeutic treatments were the ...
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The Chymopapain Clinical Trials
Neurosurgery, 1985Abstract The three published randomized clinical trials of chymopapain injection vs. placebo injection for the treatment of herniated lumbar discs are reviewed. Despite some differences, the similarities in selection criteria, technique, and outcome assessment are great enough to justify pooling the results to obtain an overall ...
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Pharmaceutisch Weekblad Scientific Edition, 1983
Randomized controlled clinical trials are being exposed to severe criticism in recent years. It is questioned if the use of placebos in such trials is ethically justified. This and other ethical problems will be discussed in this paper. Ethical problems include, besides the use of placebos, obtainment of informed consent and the belief in 'treatment ...
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Randomized controlled clinical trials are being exposed to severe criticism in recent years. It is questioned if the use of placebos in such trials is ethically justified. This and other ethical problems will be discussed in this paper. Ethical problems include, besides the use of placebos, obtainment of informed consent and the belief in 'treatment ...
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An agenda for Clinical Trials: clinical trials in the genomic era
Clinical Trials, 2004The mantra of many clinical trialists has been to do randomized clinical trials with broad eligibility and avoid subset analysis. Developments in cancer research, however, have raised some questions about this approach in the genomic era of molecularly targeted therapeutics.
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Where are clinical trials going? Society and clinical trials
Journal of Internal Medicine, 2004Abstract.Clinical trials now increasingly impinge on society at large. First there is growing emphasis from health organizations on the need for unbiased evidence about the effectiveness of promoted remedies. Second, as most novel treatments accrue increased costs to society, these need to be evaluated in terms of value for money. Third, there has been
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