Results 71 to 80 of about 7,990,092 (312)

A statistical investigation of fraud and misconduct in clinical trials [PDF]

Research misconduct can arise In any area of research and can discredit the findings. Research misconduct at any level is unacceptable, especially in a clinical trial.
Al-Marzouki, Sanaa Mohammed
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Clinical Medicine and Clinical Trials [PDF]

The Oncologist, 2010
The author discusses the role of clinical trials in clinical medicine.
openaire   +2 more sources

Clinical trials profile: Professionals and sites

, 2010
Clinical trial is considered a breakthrough method in medicine and essential to the development of new drugs. Clinical trials that comply with international and national regulations require an appropriate infrastructure and team qualification.
Marcelo E. Nita, Flair J. Carrilho, ONO-NITA, Suzane Kioko, BARBOSA, Fernanda R., Helena S. Paschoale, NITA, Marcelo E., Fernanda R. Barbosa, CARRILHO, Flair J., Suzane Kioko Ono-Nita, PASCHOALE, Helena S.   +9 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Association Between Malaria Parasite Geometrical Mean and Clinical Spectrum of Severe Disease in a High-Transmission Setting in Eastern Uganda: A Cross-Sectional Study

Journal of Parasitology Research
Conclusion: In malaria high-transmission settings of Eastern Uganda, patients with severe malaria had low parasite GMs similar to those in uncomplicated malaria.
Emma Isaiah Eregu Egiru, Cate Namayanja, George Paasi, William Okiror, Paul Ongodia, Charles Benard Okalebo, Rita Muhindo, Grace Abongo, Faith Oguttu, Ambrose Okibure, Francis Okello, Crispus Tegu, David Mukunya, Martin Chebet, Peter Olupot-Olupot   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Understanding implementability in clinical trials: a pragmatic review and concept map.

BackgroundThe translation of evidence from clinical trials into practice is complex. One approach to facilitating this translation is to consider the 'implementability' of trials as they are designed and conducted.
Australian Clinical Trials Alliance Reference Group on Impact and Implementation of CTN Trials, Sharplin, Greg, Webb, Steven A, Green, Sally, Middleton, Philippa, Cumpston, Miranda S   +5 more
core   +1 more source

Decentralised, patient-centric, site-less, virtual, and digital clinical trials?: From confusion to consensus

, 2023
There is increasing interest in clinical trials that use technologies and other innovative operational approaches to organise trial activities around trial participants instead of investigator sites.
Trials@Home Consortium
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