Results 131 to 140 of about 635,069 (409)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19

Drug Design, Development and Therapy, 2020
Weilong Zhang,1,* Yinghua Lv,1,* Juan Yang,1 Yunhui Chen,2 Yingchun He,1 Jihan Huang1 1Center for Drug Clinical Research, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203 ...
Zhang W, Lv Y, Yang J, Chen Y, He Y, Huang J   +5 more
doaj  

Study designs: Part 5 – interventional studies (II)

Perspectives in Clinical Research, 2019
In the fifth piece of this series on research study designs, we continue the discussion on interventional studies (clinical trials), in which the investigator decides whether or not a particular participant receives the exposure (or intervention).
Rakesh Aggarwal, Priya Ranganathan
doaj   +1 more source

Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review [PDF]

, 2018
Background: Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary information on the mean or ...
A Patil, AK Chowdhry, Christopher J. Weir, D Kwon, DJ Lunn, GALA Trial Collaborative Group, Gordon D. Murray, HA Dakin, Isabella Butcher, J Ma, JPT Higgins, JWA Stevens, K Dwan, KF Schulz, KR Abrams, L Sung, LHC Tippett, M Bland, M Boucher, M Egger, MA MacNeil, Marian C. Brady, N Wiebe, Peter Langhorne, RJ Little, RM Nixon, S Garrattini, SD Walter, SP Hozo, Stephanie C. Lewis, Valentina Assi, W Mendehall, X Wan   +32 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Position Paper on Road Map for RNA Virus Research in India

Frontiers in Microbiology, 2018
The Indian subcontinent with its population density, climatic conditions, means of subsistence, socioeconomic factors as well as travel and tourism presents a fertile ground for thriving of RNA viruses. Despite being pathogens of huge significance, there
Guruprasad R. Medigeshi, Katja Fink, Nagendra R. Hegde   +2 more
doaj   +1 more source

Adenosine as an Active Ingredient in Topical Preparations Against Hair Loss: A Systematic Review and Meta-Analysis of Published Clinical Trials

Biomolecules
Research results suggest the potential of topical adenosine as a hair-promoting agent. The aim of this study was to examine the available clinical evidence of the efficacy of topical adenosine products in hair loss. This systematic review was conducted in accordance with PRISMA and PICO guidelines and included articles indexed in PubMed, Scopus, and ...
Ewelina Szendzielorz, Radoslaw Spiewak
openaire   +3 more sources

Effect of Topical Chamomile Oil (Matricaria chamomile L.) as a Supplementary Method on Colic Symptoms in Infants: A Randomized Placebo-controlled Clinical Trial

Iranian Journal of Neonatology, 2019
Background: The aim of this study was to evaluate the efficacy of the topical use of chamomile oil as a complementary method in the improvement of infantile colic symptoms. Methods: This randomized controlled trial was carried out on 74 infants with colic at Sabzevar University of Medical Sciences in Sabzevar, Iran.
Salehipoor, Hassan, Afzali, Behzad, Akrami, Rahim, Ghorat, Fereshteh, Niktabe, Zahra, Sahebkar, Mohammad   +5 more
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Cervix Cancer Research Network (CCRN): Increasing access to cancer clinical trials in low- and middle-income countries

Frontiers in Oncology, 2015
Introduction: The burden of cervical cancer is large and growing in developing countries, due in large part to limited access to screening services and lack of human papillomavirus (HPV) vaccination.
Gita eSuneja, Monica eBacon, William eSmall, Sang Y Ryu, Henry C Kitchener, David K Gaffney   +5 more
doaj   +1 more source