Results 221 to 230 of about 1,662,629 (361)

Uptake of core outcome sets in paediatric clinical trials: a protocol. [PDF]

BMJ Paediatr Open
Lei R, Estill J, Florez ID, Li Q, Chen Y, Williamson P.   +5 more
europepmc   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Editorial: Old drugs: confronting recent advancements and challenges. [PDF]

Front Pharmacol
Wiktorowska-Owczarek A, Iacono D, Jasińska-Stroschein M.   +2 more
europepmc   +1 more source

Multi-stakeholder sessions on major innovation topics in rare disease clinical trials

Daniel Bodden, Stefanie Schoenen, Stephanie Wied, Johan Verbeeck, Maya Dirani, Hussein Abu Daya, N Heussen, Geert Molenberghs, R.-D Hilgers, Rima Nabbout   +9 more
openalex   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Editorial: Head and neck cancer in the elderly - vol II. [PDF]

Front Oncol
Szturz P, Vermorken JB.
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Past, present, and future of exosomes research in cancer: A bibliometric and visualization analysis. [PDF]

Hum Vaccin Immunother
Xie Y, Mi X, Xing Y, Dai Z, Pu Q.
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Are trial participants adequately safeguarded by the ethics committees – the Indian scenario?

Frontiers in Pharmacology, 2014
Karan eThakkar, Dr Gauri eBilla
doaj   +1 more source