Results 311 to 320 of about 1,662,629 (361)

Clinical trial of topical disodium cromoglycate in vernal kerato‐conjunctivitis

Clinical & Experimental Allergy, 1972
SummaryThe results of a double blind placebo‐controlled clinical trial of topical administration of disodium cromoglycate drops to one eye and placebo drops to the other eye in the treatment of vernal kerato‐conjunctivitis in twenty‐two patients indicates that the drug has a significant therapeutic effect. Patients vary in the degree of their response,
D. L. Easty, Barrie R. Jones, N. S. C. Rice   +2 more
openaire   +3 more sources

Muscular dystrophy: new challenges and review of the current clinical trials

Current opinion in pediatrics, 2013
Purpose of reviewWe provide a review of recent standards of care and therapeutic development in different forms of muscular dystrophies. This topic is relevant as the improved understanding of these disorders has not only led to a better definition of ...
E. Mercuri, F. Muntoni
semanticscholar   +1 more source

CONTROLLED CLINICAL TRIAL OF ORAL AND TOPICAL DIETHYLCARBAMAZINE IN TREATMENT OF ONCHOCERCIASIS

The Lancet, 1980
In a double-blind controlled clinical trial comparing the safety and efficacy of oral diethylcarbamazine citrate (DEC) with topical DEC for the treatment of onchocerciasis twenty men with moderate skin-snip microfilarial counts received daily therapy for 1 week, then weekly therapy for the rest of 6 months.
HughR. Taylor, BruceM. Greene, MauriceE Langham   +2 more
openaire   +3 more sources

Topical Fluorides: Development and Clinical Trials

1978
The aim of topical fluoride therapy is the deposition of fluoride into the surface layer of tooth enamel to form fluorapatite, so as to decrease the caries susceptibility of the tissue.
openaire   +2 more sources

Topical Application of Honey on Surgical Wounds: A Randomized Clinical Trial

Complementary Medicine Research, 2016
<b><i>Background:</i></b> The antimicrobial and anti-inflammatory activity of honey and its ability to accelerate wound healing make it an attractive option in surgical wound care. We performed a randomized clinical trial to compare the efficacy of honey dressing with conventional dressing regarding the aesthetic outcome.
Hamidreza Abtahi, Ali Atria, Shahideh Amini, Peiman Goharshenasan, Ghasemali Khorasani   +4 more
openaire   +3 more sources

Listening to placebo in clinical trials for female sexual dysfunction.

Journal of Sexual Medicine, 2013
INTRODUCTION Placebo responses are substantial in many clinical trials of treatments for female sexual dysfunctions (FSDs). Recent studies from other fields suggest a need to reconceptualize placebo response and to design future trials accordingly ...
A. Bradford
semanticscholar   +1 more source

Is TOPIC the last trial for clinically isolated syndrome?

Nature Reviews Neurology, 2014
The recent TOPIC trial found that teriflunomide could prevent relapses in patients with clinically isolated syndrome (CIS). Many other multiple sclerosis (MS) therapies are effective for CIS, because CIS is the first clinical manifestation of MS for most patients. Questions remain over the utility of future trials like TOPIC.
openaire   +2 more sources

Adaptive Randomization for Clinical Trials

Journal of Biopharmaceutical Statistics, 2012
In February 2010, the U.S. Food and Drug Administration (FDA, 2010) drafted guidance that discusses the statistical, clinical, and regulatory aspects of various adaptive designs for clinical trials.
W. Rosenberger, O. Sverdlov, F. Hu
semanticscholar   +1 more source

Bayesian adaptive clinical trials: a dream for statisticians only?

Statistics in Medicine, 2012
Adaptive or ‘flexible’ designs have emerged, mostly within frequentist frameworks, as an effective way to speed up the therapeutic evaluation process. Because of their flexibility, Bayesian methods have also been proposed for Phase I through Phase III ...
S. Chevret
semanticscholar   +1 more source

Modeling and prediction of subject accrual and event times in clinical trials: a systematic review

Clinical Trials, 2012
Background Modeling and prediction of subject accrual and event times in clinical trials has been a topic of considerable interest for important practical reasons.
Xiaoxi Zhang, Q. Long
semanticscholar   +1 more source